SCHEMBL4432966

SCHEMBL4432966

Cc1c(NC(=O)c2cccc(Cl)c2)cccc1C(F)(F)C(F)(F)F

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNMA1 Q12791 1/20 0.51
RXFP1 Q9HBX9 1/20 0.50
KCNK3 O14649 1/20 0.49
KCNK9 Q9NPC2 1/20 0.49
ABCC9 O60706 1/20 0.48
ABCC8 Q09428 1/20 0.48
KCNJ11 Q14654 1/20 0.48
KCNJ8 Q15842 1/20 0.48
MEN1 O00255 3/20 0.48
KMT2A Q03164 3/20 0.48
NPSR1 Q6W5P4 1/20 0.48
POLB P06746 1/20 0.48
L3MBTL1 Q9Y468 1/20 0.48
MAPT P10636 1/20 0.48
GAA P10253 1/20 0.47
CYP1A2 P05177 1/20 0.46
CYP3A4 P08684 1/20 0.46
CYP2D6 P10635 1/20 0.46
CYP2C9 P11712 1/20 0.46
CYP2C19 P33261 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4432968 0.80 POLB (0.54) KCNMA1RXFP1KCNK3KCNK9POLB
SCHEMBL5429717 0.78 POLB (0.54) KCNMA1RXFP1KCNK3KCNK9POLB
SCHEMBL14007286 0.76 KCNMA1 (0.71) KCNMA1KCNK3KCNK9MEN1KMT2A
SCHEMBL21870103 0.76 POLB (0.68) KCNMA1KCNK3KCNK9MEN1KMT2A
SCHEMBL5490486 0.74 TAS2R14 (0.59) KCNK3KCNK9MEN1KMT2ANPSR1
SCHEMBL2968970 0.74 MAPT (0.53) KMT2ANPSR1MAPTGAACYP1A2
SCHEMBL5257642 0.74 MAPT (0.53) KMT2ANPSR1MAPTGAACYP1A2
SCHEMBL330371 0.72 TMPRSS4 (0.68) KCNMA1MEN1KMT2A
SCHEMBL1307853 0.72 MEN1 (0.62) KCNMA1RXFP1KCNK3KCNK9MEN1
SCHEMBL1464661 0.72 MEN1 (0.79) KCNMA1RXFP1KCNK3KCNK9MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6362369-B1 None US disclosed
EP-1700844-B1 Phthalic acid diamide derivatives, agricultural and horticultural insecticides and a method for application of the insecticides NIHON NOHYAKU CO LTD (JP) 2009-01-14 EP disclosed
EP-1700844-A1 Phthalic acid diamide derivatives, agricultural and horticultural insecticides and a method for application of the insecticides Nihon Nohyaku Co., Ltd. (JP) 2006-09-13 EP disclosed
EP-1447396-A1 Phthalic acid diamide derivatives, agriculture and horticultural insecticides, and a method for application of the insecticides NIHON NOHYAKU CO., LTD. (JP) 2004-08-18 EP disclosed
US-6559341-B2 Phthalic acid diamide derivatives, fluorine-containing aniline compounds as starting material, agricultural and horticultural insecticides, and a method for application of the insecticides NIHON NOHYAKU CO., LTD. (JP) 2003-05-06 US disclosed
US-20030055287-A1 Phthalic acid diamide derivatives, fluorine-containing aniline compounds as starting material, agricultural and horticultural insecticides, and a method for application of the insecticides AIR MOTION TECHNOLOGIES, LLC 2003-03-20 US disclosed
US-6362369-B2 CONTROLLING INSECTS IN CROPS NIHON NOHYAKU CO., LTD. (JP) 2002-03-26 US disclosed
US-20010041814-A1 PHTHALIC ACID DIAMIDE DERIVATIVES FLUORINE-CONTAINING ANILINE COMPOUNDS AS STARTING MATERIAL, AGRICULTURAL AND HORTICULTURAL INSECTICIDES, AND A METHOD FOR APPLICATION OF THE INSECTICIDES NIHON NOHYAKU CO., LTD. (JP) 2001-11-15 US disclosed
EP-0919542-A2 Phthalic acid diamide derivatives, agricultural and horticultural insecticides, and a method for application of the insecticides NIHON NOHYAKU CO., LTD. (JP) 1999-06-02 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20010041814-A1 PHTHALIC ACID DIAMIDE DERIVATIVES FLUORINE-CONTAINING ANILINE COMPOUNDS AS STARTING MATERIAL, AGRICULTURAL AND HORTICULTURAL INSECTICIDES, AND A METHOD FOR APPLICATION OF THE INSECTICIDES DDT, AFF1, BCL2L2 KCNMA1 2194/4885RXFP1 275/4885KCNK3 2184/4885
US-20030055287-A1 Phthalic acid diamide derivatives, fluorine-containing aniline compounds as starting material, agricultural and horticultural insecticides, and a method for application of the insecticides DDT, BCL2A1, BCL2L2 KCNMA1 2228/4885RXFP1 315/4885KCNK3 2040/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.