Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 3/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.55 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.55 |
| ▸ | MDM4 | O15151 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6170575 | 0.85 | POLB (0.67) | POLBHPGDGAAKCNK3KCNK9 | |
| SCHEMBL30008296 | 0.85 | POLB (0.67) | POLBHPGDGAAKCNK3KCNK9 | |
| SCHEMBL11067319 | 0.85 | TAS2R14 (0.63) | TAS2R14POLBHPGDGAAHDAC6 | |
| SCHEMBL19976979 | 0.84 | TAS2R14 (0.50) | TAS2R14POLBKCNK3KCNK9HDAC1 | |
| SCHEMBL6054990 | 0.84 | ALDH1A1 (0.59) | HDAC1TP53MAPTMEN1KMT2A | |
| SCHEMBL16330055 | 0.84 | POLB (0.72) | POLBHPGDHDAC1MDM4TP53 | |
| SCHEMBL28169922 | 0.82 | SMN1; SMN2 (0.59) | POLBHPGDGAAKCNK3KCNK9 | |
| SCHEMBL28316791 | 0.82 | POLB (0.57) | POLBHPGDGAAHDAC1MDM4 | |
| SCHEMBL23167346 | 0.81 | TAS2R14 (0.58) | TAS2R14POLBHPGDGAAHDAC6 | |
| SCHEMBL30152395 | 0.81 | TAS2R14 (0.58) | TAS2R14POLBHPGDGAAHDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836174-A2 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC. (US) | 2007-09-26 | — | — | EP | claimed |
| WO-2006039718-A2 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC (US) | 2006-04-13 | — | — | WO | claimed |