SCHEMBL4432968

SCHEMBL4432968

Cc1cc(C(F)(F)C(F)(F)F)ccc1NC(=O)c1cccc(Cl)c1

nearest known ligand 0.56

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.54
GAA P10253 2/20 0.53
KCNMA1 Q12791 1/20 0.51
RXFP1 Q9HBX9 1/20 0.50
KCNK3 O14649 2/20 0.49
KCNK9 Q9NPC2 2/20 0.49
CYP1A2 P05177 3/20 0.48
CYP2C19 P33261 3/20 0.48
MAPT P10636 1/20 0.48
CYP2C9 P11712 1/20 0.48
SMN1; SMN2 Q16637 1/20 0.47
CYP2D6 P10635 2/20 0.47
RAB9A P51151 2/20 0.47
CYP3A4 P08684 1/20 0.46
NPC1 O15118 1/20 0.46
CASP3 P42574 1/20 0.46
SENP7 Q9BQF6 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5429717 0.90 POLB (0.54) POLBGAAKCNMA1RXFP1KCNK3
SCHEMBL4432966 0.80 KCNMA1 (0.51) POLBGAAKCNMA1RXFP1KCNK3
SCHEMBL28584128 0.79 MAPT (0.72) POLBKCNMA1KCNK3KCNK9CYP1A2
SCHEMBL21870103 0.78 POLB (0.68) POLBGAAKCNMA1KCNK3KCNK9
SCHEMBL21385245 0.78 RXFP1 (0.62) GAAKCNMA1RXFP1KCNK3KCNK9
SCHEMBL11819922 0.77 MAPT (0.68) POLBKCNMA1RXFP1CYP1A2CYP2C19
SCHEMBL28595259 0.75 RAB9A (0.67) POLBGAACYP2C19MAPTSMN1; SMN2
SCHEMBL7572659 0.73 KMT2A (0.69) POLBRXFP1CYP1A2CYP2C19SMN1; SMN2
SCHEMBL7302951 0.73 SERPINE1 (0.71) POLBKCNK9CYP1A2CYP2C19SMN1; SMN2
SCHEMBL14007286 0.73 KCNMA1 (0.71) KCNMA1KCNK3KCNK9MAPTRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6362369-B1 None US disclosed
EP-1700844-B1 Phthalic acid diamide derivatives, agricultural and horticultural insecticides and a method for application of the insecticides NIHON NOHYAKU CO LTD (JP) 2009-01-14 EP disclosed
EP-1700844-A1 Phthalic acid diamide derivatives, agricultural and horticultural insecticides and a method for application of the insecticides Nihon Nohyaku Co., Ltd. (JP) 2006-09-13 EP disclosed
EP-1447396-A1 Phthalic acid diamide derivatives, agriculture and horticultural insecticides, and a method for application of the insecticides NIHON NOHYAKU CO., LTD. (JP) 2004-08-18 EP disclosed
US-6559341-B2 Phthalic acid diamide derivatives, fluorine-containing aniline compounds as starting material, agricultural and horticultural insecticides, and a method for application of the insecticides NIHON NOHYAKU CO., LTD. (JP) 2003-05-06 US disclosed
US-20030055287-A1 Phthalic acid diamide derivatives, fluorine-containing aniline compounds as starting material, agricultural and horticultural insecticides, and a method for application of the insecticides AIR MOTION TECHNOLOGIES, LLC 2003-03-20 US disclosed
US-6362369-B2 CONTROLLING INSECTS IN CROPS NIHON NOHYAKU CO., LTD. (JP) 2002-03-26 US disclosed
US-20010041814-A1 PHTHALIC ACID DIAMIDE DERIVATIVES FLUORINE-CONTAINING ANILINE COMPOUNDS AS STARTING MATERIAL, AGRICULTURAL AND HORTICULTURAL INSECTICIDES, AND A METHOD FOR APPLICATION OF THE INSECTICIDES NIHON NOHYAKU CO., LTD. (JP) 2001-11-15 US disclosed
EP-0919542-A2 Phthalic acid diamide derivatives, agricultural and horticultural insecticides, and a method for application of the insecticides NIHON NOHYAKU CO., LTD. (JP) 1999-06-02 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20010041814-A1 PHTHALIC ACID DIAMIDE DERIVATIVES FLUORINE-CONTAINING ANILINE COMPOUNDS AS STARTING MATERIAL, AGRICULTURAL AND HORTICULTURAL INSECTICIDES, AND A METHOD FOR APPLICATION OF THE INSECTICIDES DDT, AFF1, BCL2L2 POLB 3694/4885GAA 4577/4885KCNMA1 2194/4885
US-20030055287-A1 Phthalic acid diamide derivatives, fluorine-containing aniline compounds as starting material, agricultural and horticultural insecticides, and a method for application of the insecticides DDT, BCL2A1, BCL2L2 POLB 3972/4885GAA 4645/4885KCNMA1 2228/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.