Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 1/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | GABBR2 | O75899 | 6/20 | 0.40 |
| ▸ | GABBR1 | Q9UBS5 | 6/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8239806 | 0.81 | ADRB2 (0.48) | ADRB2GABBR2GABBR1LMNACYP2C9 | |
| SCHEMBL13784991 | 0.81 | ADRA2A (0.38) | CYP1A2CYP2D6TSHRPMP22ADRA2A | |
| SCHEMBL3621043 | 0.80 | ADRB2 (0.42) | ADRB2GABBR2GABBR1LMNACYP2C9 | |
| SCHEMBL3621046 | 0.80 | ADRB2 (0.42) | ADRB2GABBR2GABBR1LMNACYP2C9 | |
| SCHEMBL18102233 | 0.79 | ADRB2 (0.41) | ADRB2GABBR2GABBR1LMNACYP2C9 | |
| SCHEMBL6278627 | 0.78 | GABBR2 (0.56) | ADRB2SLC6A3GABBR2GABBR1LMNA | |
| SCHEMBL19803301 | 0.78 | GABBR2 (0.56) | ADRB2SLC6A3GABBR2GABBR1LMNA | |
| SCHEMBL19803214 | 0.78 | GABBR2 (0.56) | ADRB2SLC6A3GABBR2GABBR1LMNA | |
| SCHEMBL27644590 | 0.78 | GABBR2 (0.49) | GABBR2GABBR1LMNACYP2C9CYP1A2 | |
| SCHEMBL11493799 | 0.77 | CYP17A1 (0.40) | GABBR2GABBR1ADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114906-A1 | NOVEL 2-AMINOOXAZOLINES AS TAAR1 LIGANDS FOR CNS DISORDERS | F. Hoffmann-Roche AG (CH) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008092785-A1 | NOVEL 2-AMINOOXAZOLINES AS TAAR1 LIGANDS FOR CNS DISORDERS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-08-07 | — | — | WO | disclosed |