Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 7/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.74 |
| ▸ | NPSR1 | Q6W5P4 | 6/20 | 0.35 |
| ▸ | HPGD | P15428 | 5/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.35 |
| ▸ | TP53 | P04637 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 4/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.33 |
| ▸ | STAT3 | P40763 | 3/20 | 0.33 |
| ▸ | MITF | O75030 | 2/20 | 0.33 |
| ▸ | BPTF | Q12830 | 1/20 | 0.33 |
| ▸ | SDHB | P21912 | 3/20 | 0.32 |
| ▸ | RAB9A | P51151 | 3/20 | 0.32 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1067726 | 0.85 | SMN1; SMN2 (1.00) | LMNASMN1; SMN2NPSR1HPGDKMT2A | |
| SCHEMBL6561352 | 0.74 | SMN1; SMN2 (0.78) | LMNASMN1; SMN2NPSR1HPGDKMT2A | |
| SCHEMBL5360302 | 0.74 | LMNA (0.78) | LMNASMN1; SMN2NPSR1HPGDKMT2A | |
| SCHEMBL8666206 | 0.74 | SMN1; SMN2 (0.78) | LMNASMN1; SMN2NPSR1HPGDKMT2A | |
| SCHEMBL6806477 | 0.73 | LMNA (0.75) | LMNASMN1; SMN2NPSR1HPGDKMT2A | |
| SCHEMBL9432915 | 0.73 | LMNA (0.73) | LMNASMN1; SMN2NPSR1HPGDKMT2A | |
| SCHEMBL8953787 | 0.72 | SMN1; SMN2 (0.62) | LMNASMN1; SMN2NPSR1HPGDKMT2A | |
| SCHEMBL9903777 | 0.72 | LMNA (0.62) | LMNASMN1; SMN2NPSR1HPGDKMT2A | |
| SCHEMBL9902644 | 0.72 | LMNA (0.62) | LMNASMN1; SMN2NPSR1HPGDKMT2A | |
| SCHEMBL14026680 | 0.72 | PDE2A (0.45) | LMNASMN1; SMN2KDM4EALDH1A1NNMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118073-A2 | SELECTIVE ENDOTHELIN TYPE-A ANTAGONISTS | Concert Pharmaceuticals Inc. (US) | 2009-11-18 | — | — | EP | disclosed |
| US-20080262006-A1 | Selective endothelin type-a antagonists | CONCERT PHARMACEUTICALS, INC. | 2008-10-23 | — | — | US | disclosed |
| US-20080262006-A1 | Selective endothelin type-a antagonists | CONCERT PHARMACEUTICALS, INC. | 2008-10-23 | — | — | US | disclosed |
| WO-2008097468-A2 | SELECTIVE ENDOTHELIN TYPE-A ANTAGONISTS | CONCERT PHARMACEUTICALS, INC. (US) | 2008-08-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080262006-A1 | Selective endothelin type-a antagonists | EDNRA, EDNRB, ECE1 | LMNA 1125/4885SMN1; SMN2 3421/4885NPSR1 86/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.