Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 7/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.62 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | SDHB | P21912 | 8/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 7/20 | 0.35 |
| ▸ | HPGD | P15428 | 6/20 | 0.35 |
| ▸ | TP53 | P04637 | 5/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.35 |
| ▸ | HTT | P42858 | 5/20 | 0.35 |
| ▸ | STAT3 | P40763 | 4/20 | 0.35 |
| ▸ | RAB9A | P51151 | 4/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.35 |
| ▸ | STAT1 | P42224 | 2/20 | 0.35 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.35 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28858783 | 0.78 | LMNA (0.42) | LMNASMN1; SMN2PTGS1PTGS2NPSR1 | |
| SCHEMBL1067726 | 0.77 | SMN1; SMN2 (1.00) | LMNASMN1; SMN2PTGS2NPSR1HPGD | |
| SCHEMBL8953787 | 0.72 | SMN1; SMN2 (0.62) | LMNASMN1; SMN2PTGS2SDHBNPSR1 | |
| SCHEMBL4433293 | 0.72 | LMNA (0.74) | LMNASMN1; SMN2PTGS2SDHBNPSR1 | |
| SCHEMBL9902644 | 0.72 | LMNA (0.62) | LMNASMN1; SMN2PTGS1PTGS2SDHB | |
| SCHEMBL3825378 | 0.72 | GAA (0.44) | SMN1; SMN2PTGS1PTGS2NPSR1HPGD | |
| SCHEMBL38662046 | 0.71 | LMNA (0.60) | LMNASMN1; SMN2SDHBNPSR1HPGD | |
| SCHEMBL9329671 | 0.71 | LMNA (0.60) | LMNASMN1; SMN2SDHBNPSR1HPGD | |
| SCHEMBL9903569 | 0.71 | SMN1; SMN2 (0.55) | LMNASMN1; SMN2PTGS1PTGS2NPSR1 | |
| SCHEMBL9905300 | 0.69 | LMNA (0.58) | LMNASMN1; SMN2PTGS1PTGS2TLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2463277-B1 | METHOD FOR PRODUCING 4,6-DIALKOXY-2-CYANOMETHYLPYRIMIDINE AND SYNTHETIC INTERMEDIATE THEREOF | KUMIAI CHEMICAL INDUSTRY CO (JP) | 2017-11-08 | — | — | EP | disclosed |
| US-9573907-B2 | 2, 4-pyrimidine derivatives and use thereof | SNU R&DB FOUNDATION (KR) | 2017-02-21 | — | — | US | disclosed |
| EP-2497768-B1 | NOVEL 2, 4-PYRIMIDINE DERIVATIVES AND USE THEREOF | SNU R&DB FOUNDATION (KR) | 2016-04-20 | — | — | EP | disclosed |
| CN-105130908-A | Method for producing 4,6-dialkoxy-2-cyanomethylpyrimidine and synthetic intermediate thereof | IHARA CHEMICAL IND CO | 2015-12-09 | — | — | CN | disclosed |
| CN-102548972-B | Preparation method of 4, 6-dialkoxy-2-cyanomethylpyrimidine and synthetic intermediate thereof | IHARA CHEMICAL INDUSTRY CO.,LTD. (JP) | 2015-08-19 | — | — | CN | disclosed |
| US-8748605-B2 | Method for producing 4,6-dialkoxy-2-cyanomethylpyrimidine and synthetic intermediate thereof | IHARA CHEMICAL INDUSTRY CO., LTD. (JP) | 2014-06-10 | — | — | US | disclosed |
| US-20120322802-A1 | NOVEL 2, 4-PYRIMIDINE DERIVATIVES AND USE THEREOF | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2012-12-20 | — | — | US | disclosed |
| EP-2497768-A2 | NOVEL 2, 4-PYRIMIDINE DERIVATIVES AND USE THEREOF | SNU R&DB Foundation (KR) | 2012-09-12 | — | — | EP | disclosed |
| US-20120190851-A1 | METHOD FOR PRODUCING 4,6-DIALKOXY-2-CYANOMETHYLPYRIMIDINE AND SYNTHETIC INTERMEDIATE THEREOF | IHARA CHEMICAL INDUSTRY CO., LTD. (JP) | 2012-07-26 | — | — | US | disclosed |
| EP-2463277-A1 | METHOD FOR PRODUCING 4,6-DIALKOXY-2-CYANOMETHYLPYRIMIDINE AND SYNTHETIC INTERMEDIATE THEREOF | Ihara Chemical Industry Co., Ltd. (JP) | 2012-06-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120322802-A1 | NOVEL 2, 4-PYRIMIDINE DERIVATIVES AND USE THEREOF | LY96, AIMP1, NLRP1 | LMNA 1256/4885SMN1; SMN2 4581/4885PTGS1 2642/4885 |
| US-20120190851-A1 | METHOD FOR PRODUCING 4,6-DIALKOXY-2-CYANOMETHYLPYRIMIDINE AND SYNTHETIC INTERMEDIATE THEREOF | DPYD, TYMP, DTYMK | LMNA 3856/4885SMN1; SMN2 2788/4885PTGS1 1571/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.