Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 6/20 | 0.35 |
| ▸ | XDH | P47989 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | IDO1 | P14902 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | PPARD | Q03181 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4433371 | 0.87 | PPARA (0.37) | GPR52PPARAXDHSMN1; SMN2KDM4E | |
| SCHEMBL4422309 | 0.83 | GAA (0.52) | SMN1; SMN2KDM4EALDH1A1LMNAMAPT | |
| SCHEMBL4277759 | 0.75 | PTGER1 (0.48) | GPR52XDHSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL3856745 | 0.75 | PTGER1 (0.49) | SMN1; SMN2MAPTHTTPTGER1 | |
| Hydrochloric Acid SCHEMBL4279956 | 0.75 | PTGER1 (0.48) | GPR52XDHSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL4425380 | 0.74 | MTNR1B (0.37) | GPR52 | |
| SCHEMBL13573316 | 0.73 | ESR2 (0.48) | SMN1; SMN2HTTPTGER1 | |
| SCHEMBL4022473 | 0.73 | PTGDR2 (0.38) | SMN1; SMN2ALDH1A1LMNAMAPTHTT | |
| SCHEMBL3666731 | 0.72 | KDM1A (0.41) | — | |
| SCHEMBL4553186 | 0.72 | FFAR1 (0.44) | SMN1; SMN2LMNAMAPTHTTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009150196-A1 | N-THIAZOLYL-1, 2, 3, 4-TETRAHYDRO-6-ISOQUINOLINECARBOXAMIDE DERIVATIVES AS INHIBITORS OF STEAROYL COENZYME A DESATURASE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-12-17 | — | — | WO | disclosed |