SCHEMBL4433724

SCHEMBL4433724

CC(C)[C@H](NS(=O)(=O)c1ccc(-c2ccc(Br)cc2)cc1)C(=O)O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
MMP2 P08253 17/20 1.00
MMP3 P08254 15/20 1.00
MMP13 P45452 15/20 1.00
MMP1 P03956 14/20 1.00
MMP7 P09237 14/20 1.00
MMP9 P14780 14/20 1.00
MMP14 P50281 1/20 1.00
ADAMTS4 O75173 3/20 0.78
MMP8 P22894 1/20 0.71

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7404078 1.00 MMP2 (1.00) MMP2MMP3MMP13MMP1MMP7
SCHEMBL4424095 1.00 MMP2 (1.00) MMP2MMP3MMP13MMP1MMP7
SCHEMBL8283336 0.95 MMP2 (0.91) MMP2MMP3MMP13MMP1MMP7
SCHEMBL27611876 0.95 MMP2 (0.91) MMP2MMP3MMP13MMP1MMP7
SCHEMBL4653257 0.88 MMP2 (1.00) MMP2MMP3MMP13MMP1MMP7
SCHEMBL32691806 0.88 MMP2 (1.00) MMP2MMP3MMP13MMP1MMP7
SCHEMBL1750956 0.88 MMP2 (1.00) MMP2MMP3MMP13MMP1MMP7
SCHEMBL7082523 0.87 MMP2 (1.00) MMP2MMP3MMP13MMP1MMP7
SCHEMBL7864111 0.87 MMP2 (1.00) MMP2MMP3MMP13MMP1MMP7
SCHEMBL7409278 0.87 MMP2 (1.00) MMP2MMP3MMP13MMP1MMP7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 89 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4744663-A2 SKIN COMPOSITION Eaderm Co., Ltd. (JP) 2026-05-20 EP claimed
US-12548678-B2 Methods and systems for machine learning analysis of single nucleotide polymorphisms in lupus AMPEL BIOSOLUTIONS, LLC (US) 2026-02-10 US claimed
US-20240269138-A1 MMP13 AS A THERAPEUTIC TARGET FOR ALLERGIC INFLAMMATORY DISEASES MASSACHUSETTS GEN HOSPITAL (US) 2024-08-15 US claimed
CN-109310775-B Binary self-assembling gels for controlled delivery of encapsulated agents into cartilage 布里格姆及妇女医院股份有限公司 2022-11-18 CN claimed
US-20220331389-A1 SKIN COMPOSITION EADERM CO., LTD. (JP) 2022-10-20 US claimed
US-11298372-B2 Composition for ameliorating loss of hair and graying of hair, and use thereof NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY (JP) 2022-04-12 US claimed
EP-3978022-A1 BINARY SELF ASSEMBLED GELS FOR CONTROLLED DELIVERY OF ENCAPSULATED AGENTS TO CARTILAGE The Brigham and Women's Hospital, Inc. (US) 2022-04-06 EP claimed
EP-3978020-A1 SKIN COMPOSITION National University Corporation Tokyo Medical and Dental University (JP) 2022-04-06 EP claimed
EP-0901466-B1 BIPHENYLSULFONAMIDE MATRIX METALLOPROTEINASE INHIBITORS WARNER LAMBERT CO (US) 2001-10-31 EP claimed
CN-1310629-A Combined administration of ACAT and MMP inhibitors for the treatment of atherosclerotic lesions WARNER LAMBERT CO (US) 2001-08-29 CN claimed
EP-1098662-A2 COADMINISTRATION OF ACAT AND MMP INHIBITORS FOR THE TREATMENT OF ATHEROSCLEROTIC LESIONS WARNER-LAMBERT COMPANY (US) 2001-05-16 EP claimed
WO-2000004892-A2 COADMINISTRATION OF ACAT AND MMP INHIBITORS FOR THE TREATMENT OF ATHEROSCLEROTIC LESIONS WARNER-LAMBERT COMPANY (US) 2000-02-03 WO claimed
EP-0901466-A1 BIPHENYLSULFONAMIDE MATRIX METALLOPROTEINASE INHIBITORS WARNER-LAMBERT COMPANY (US) 1999-03-17 EP claimed
US-5756545-A ANTIARTHRITIC AGENTS; OSTEOPOROSIS WARNER-LAMBERT COMPANY (US) 1998-05-26 US claimed
WO-1997044315-A1 BIPHENYLSULFONAMIDE MATRIX METALLOPROTEINASE INHIBITORS WARNER-LAMBERT COMPANY (US) 1997-11-27 WO claimed
US-20260137788-A1 INFLAMMATION STIMULI RESPONSIVE PEPTIDE BRUSH POLYMERS NORTHWESTERN UNIVERSITY (US) 2026-05-21 US disclosed
EP-4744663-A2 SKIN COMPOSITION Eaderm Co., Ltd. (JP) 2026-05-20 EP disclosed
WO-1999047138-A1 STATIN-MATRIX METALLOPROTEINASE INHIBITOR COMBINATIONS WARNER-LAMBERT COMPANY (US) 1999-09-23 WO disclosed
WO-1999032150-A1 ACE INHIBITOR-MMP INHIBITOR COMBINATIONS WARNER-LAMBERT COMPANY (US) 1999-07-01 WO disclosed
US-5756545-A ANTIARTHRITIC AGENTS; OSTEOPOROSIS WARNER-LAMBERT COMPANY (US) 1998-05-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260137788-A1 INFLAMMATION STIMULI RESPONSIVE PEPTIDE BRUSH POLYMERS FPR1, FPR2, NPY1R MMP2 1193/4885MMP3 785/4885MMP13 944/4885
US-12548678-B2 Methods and systems for machine learning analysis of single nucleotide polymorphisms in lupus SSB, METTL16, TLR9 MMP2 1500/4885MMP3 220/4885MMP13 430/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.