Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 7/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.34 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4434940 | 0.90 | MEN1 (0.39) | HCAR3MEN1KMT2AHTTLMNA | |
| SCHEMBL4444969 | 0.88 | VCAM1 (0.42) | HCAR3MEN1KMT2AHTTLMNA | |
| SCHEMBL4444773 | 0.88 | HTT (0.38) | HCAR3MEN1KMT2AHTTLMNA | |
| SCHEMBL4433895 | 0.88 | KDM4E (0.39) | HCAR3MEN1KMT2ALMNACYP3A4 | |
| SCHEMBL4434450 | 0.87 | TACR1 (0.38) | MEN1KMT2AHTTMAPTL3MBTL1 | |
| SCHEMBL4444516 | 0.87 | MAPK1 (0.40) | MEN1KMT2AHTTLMNANPC1 | |
| SCHEMBL4439400 | 0.86 | POLB (0.40) | MEN1KMT2ALMNANPC1RAB9A | |
| SCHEMBL4437504 | 0.86 | MAPT (0.45) | MEN1KMT2ALMNAMAPTCYP1A2 | |
| SCHEMBL4445145 | 0.85 | CYP2C9 (0.41) | MEN1KMT2AHTTLMNANPC1 | |
| SCHEMBL4438391 | 0.84 | KMT2A (0.36) | KMT2AHTTLMNAMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2132177-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | Novartis Ag (CH) | 2009-12-16 | — | — | EP | disclosed |
| WO-2008106692-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2008-09-04 | — | — | WO | disclosed |