Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MITF | O75030 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CCR6 | P51684 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4433895 | 0.87 | KDM4E (0.39) | ALDH1A1KDM4EKMT2AMEN1LMNA | |
| SCHEMBL4434450 | 0.86 | TACR1 (0.38) | ALDH1A1HTTKMT2AMEN1MAPT | |
| SCHEMBL4444516 | 0.86 | MAPK1 (0.40) | ALDH1A1HTTKMT2AMEN1MAPT | |
| SCHEMBL4437157 | 0.85 | HCAR3 (0.39) | CYP2C9HTTKDM4EVCAM1KMT2A | |
| SCHEMBL4437504 | 0.85 | MAPT (0.45) | CYP2C9ALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL4439400 | 0.85 | POLB (0.40) | ALDH1A1KDM4EKMT2AMEN1MAPT | |
| SCHEMBL4434940 | 0.83 | MEN1 (0.39) | HTTKDM4EVCAM1KMT2AMEN1 | |
| SCHEMBL4438391 | 0.83 | KMT2A (0.36) | CYP2C9ALDH1A1HTTKDM4EKMT2A | |
| SCHEMBL4444969 | 0.82 | VCAM1 (0.42) | ALDH1A1HTTKDM4EVCAM1KMT2A | |
| SCHEMBL4434425 | 0.81 | KDM4E (0.39) | ALDH1A1KDM4EKMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2132177-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | Novartis Ag (CH) | 2009-12-16 | — | — | EP | disclosed |
| WO-2008106692-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2008-09-04 | — | — | WO | disclosed |