Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4444305 | 0.96 | KCNH2 (0.47) | KCNH2TNKS2GRIN1NPC1RAB9A | |
| SCHEMBL4447182 | 0.82 | PRKCZ (0.39) | NPC1RAB9AKMT2AGRM2 | |
| SCHEMBL3591845 | 0.78 | TNKS2 (0.42) | KCNH2TNKS2GRIN1KMT2AGRM5 | |
| SCHEMBL8789320 | 0.78 | GRM2 (0.43) | KMT2AGRM2 | |
| SCHEMBL4439837 | 0.78 | SCN9A (0.42) | KMT2AMCHR1GRM2 | |
| SCHEMBL4439090 | 0.78 | SCN9A (0.42) | KMT2AMCHR1GRM2 | |
| SCHEMBL4437663 | 0.78 | SCN9A (0.42) | KMT2AMCHR1GRM2 | |
| SCHEMBL3591294 | 0.73 | TNKS2 (0.45) | KCNH2TNKS2GRIN1KMT2AGRM5 | |
| SCHEMBL3589103 | 0.73 | CTSG (0.38) | KCNH2TNKS2GRIN1MCHR1 | |
| SCHEMBL4439973 | 0.70 | PBRM1 (0.44) | KMT2AGRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121598-A2 | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF CANNABINOID RECEPTOR 1 ACTIVITY | IRM LLC (BM) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008076754-A2 | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF CANNABINOID RECEPTOR 1 ACTIVITY | IRM LLC (BM) | 2008-06-26 | — | — | WO | disclosed |