Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | GUSB | P08236 | 1/20 | 0.39 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4437663 | 1.00 | SCN9A (0.42) | SCN9AHTTLMNAMAPTGRM2 | |
| SCHEMBL4439837 | 1.00 | SCN9A (0.42) | SCN9AHTTLMNAMAPTGRM2 | |
| SCHEMBL4439973 | 0.93 | PBRM1 (0.44) | HTTLMNAMAPTGRM2PBRM1 | |
| SCHEMBL4439829 | 0.89 | ALDH1A1 (0.41) | SCN9AHTTLMNAMAPTCYP3A4 | |
| SCHEMBL4438948 | 0.88 | LMNA (0.38) | SCN9AHTTLMNAMAPTGRM2 | |
| SCHEMBL4435472 | 0.88 | LMNA (0.38) | SCN9AHTTLMNAMAPTGRM2 | |
| SCHEMBL4439891 | 0.87 | FNTA (0.38) | SCN9AHTTLMNAMAPTCYP2C9 | |
| SCHEMBL4440072 | 0.86 | LMNA (0.39) | SCN9AHTTLMNAMAPTMEN1 | |
| SCHEMBL4447058 | 0.84 | MAPT (0.36) | SCN9AHTTLMNAMAPTMEN1 | |
| SCHEMBL4444360 | 0.84 | LMNA (0.40) | SCN9AHTTLMNAMAPTGRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121598-A2 | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF CANNABINOID RECEPTOR 1 ACTIVITY | IRM LLC (BM) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008076754-A2 | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF CANNABINOID RECEPTOR 1 ACTIVITY | IRM LLC (BM) | 2008-06-26 | — | — | WO | disclosed |