Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 9/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 9/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | DAGLB | Q8NCG7 | 1/20 | 0.39 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.39 |
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4433136 | 0.89 | KEAP1 (0.46) | TP53KEAP1NFE2L2SMN1; SMN2ALDH1A1 | |
| SCHEMBL4435081 | 0.89 | TP53 (0.42) | TP53KEAP1NFE2L2SMN1; SMN2ALDH1A1 | |
| SCHEMBL10317101 | 0.88 | HTR6 (0.44) | TP53KEAP1NFE2L2SMN1; SMN2ALDH1A1 | |
| SCHEMBL13389990 | 0.84 | TRPM8 (0.37) | TP53TRPM8S1PR1 | |
| SCHEMBL2846006 | 0.81 | PLAU (0.41) | TP53KEAP1NFE2L2SMN1; SMN2ALDH1A1 | |
| SCHEMBL2841946 | 0.81 | OXTR (0.48) | TP53KEAP1NFE2L2ALDH1A1L3MBTL1 | |
| SCHEMBL2850695 | 0.81 | TP53 (0.44) | TP53KEAP1NFE2L2SMN1; SMN2ALDH1A1 | |
| SCHEMBL4438874 | 0.80 | SMN1; SMN2 (0.48) | TP53KEAP1NFE2L2SMN1; SMN2ALDH1A1 | |
| SCHEMBL2843641 | 0.80 | KEAP1 (0.46) | TP53KEAP1NFE2L2SMN1; SMN2ALDH1A1 | |
| SCHEMBL2848207 | 0.80 | KEAP1 (0.41) | TP53KEAP1NFE2L2SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121600-B1 | SUBSTITUTED ARYLSULPHONYLGLYCINES, THE PREPARATION THEREOF AND THE USE THEREOF AS PHARMACEUTICAL COMPOSITIONS | BOEHRINGER INGELHEIM INT (DE) | 2012-07-18 | — | — | EP | disclosed |
| EP-2121600-A2 | SUBSTITUTED ARYLSULPHONYLGLYCINES, THE PREPARATION THEREOF AND THE USE THEREOF AS PHARMACEUTICAL COMPOSITIONS | Boehringer Ingelheim International GmbH (DE) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008099000-A2 | SUBSTITUTED ARYLSULPHONYLGLYCINES, THE PREPARATION THEREOF AND THE USE THEREOF AS PHARMACEUTICAL COMPOSITIONS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-08-21 | — | — | WO | disclosed |