Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | KEAP1 | Q14145 | 11/20 | 0.46 |
| ▸ | NFE2L2 | Q16236 | 11/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13390300 | 0.86 | RAB9A (0.39) | SMN1; SMN2TP53ALDH1A1KDM4ETHRB | |
| SCHEMBL2841946 | 0.83 | OXTR (0.48) | TP53KEAP1NFE2L2ALDH1A1 | |
| SCHEMBL2843641 | 0.83 | KEAP1 (0.46) | SMN1; SMN2TP53KEAP1NFE2L2ALDH1A1 | |
| SCHEMBL4433136 | 0.83 | KEAP1 (0.46) | SMN1; SMN2TP53KEAP1NFE2L2ALDH1A1 | |
| SCHEMBL4428459 | 0.81 | TP53 (0.47) | SMN1; SMN2TP53KEAP1NFE2L2ALDH1A1 | |
| SCHEMBL4434288 | 0.80 | TP53 (0.43) | SMN1; SMN2TP53KEAP1NFE2L2ALDH1A1 | |
| SCHEMBL10317101 | 0.80 | HTR6 (0.44) | SMN1; SMN2TP53KEAP1NFE2L2ALDH1A1 | |
| SCHEMBL4435081 | 0.78 | TP53 (0.42) | SMN1; SMN2TP53KEAP1NFE2L2ALDH1A1 | |
| SCHEMBL14089144 | 0.77 | TP53 (0.46) | SMN1; SMN2TP53KEAP1NFE2L2ALDH1A1 | |
| SCHEMBL3299041 | 0.77 | KDM4E (0.39) | SMN1; SMN2TP53ALDH1A1KDM4ETHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121600-B1 | SUBSTITUTED ARYLSULPHONYLGLYCINES, THE PREPARATION THEREOF AND THE USE THEREOF AS PHARMACEUTICAL COMPOSITIONS | BOEHRINGER INGELHEIM INT (DE) | 2012-07-18 | — | — | EP | disclosed |
| EP-2121600-A2 | SUBSTITUTED ARYLSULPHONYLGLYCINES, THE PREPARATION THEREOF AND THE USE THEREOF AS PHARMACEUTICAL COMPOSITIONS | Boehringer Ingelheim International GmbH (DE) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008099000-A2 | SUBSTITUTED ARYLSULPHONYLGLYCINES, THE PREPARATION THEREOF AND THE USE THEREOF AS PHARMACEUTICAL COMPOSITIONS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-08-21 | — | — | WO | disclosed |