Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 8/20 | 0.47 |
| ▸ | DRD2 | P14416 | 2/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | PLD1 | Q13393 | 10/20 | 0.45 |
| ▸ | PLD2 | O14939 | 9/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5000658 | 0.91 | PLD1 (0.47) | OPRM1DRD2HTR1AADRA2AHTR2A | |
| SCHEMBL4438708 | 0.87 | PLD1 (0.48) | OPRM1DRD2HTR1AADRA2AHTR2A | |
| SCHEMBL4440071 | 0.79 | YEATS4 (0.62) | OPRM1DRD2HTR1AADRA2AHTR2A | |
| Hydrochloric Acid SCHEMBL4443261 | 0.78 | YEATS4 (0.61) | OPRM1DRD2HTR1AADRA2AHTR2A | |
| SCHEMBL4446718 | 0.77 | OPRM1 (0.42) | OPRM1PLD1PLD2CHRM1 | |
| SCHEMBL4444801 | 0.75 | OPRM1 (0.42) | OPRM1DRD2PLD1PLD2CHRM1 | |
| SCHEMBL5000726 | 0.74 | PLD2 (0.53) | OPRM1DRD2HTR1AADRA2AHTR2A | |
| SCHEMBL4439022 | 0.74 | PLD2 (0.55) | OPRM1DRD2HTR1AADRA2AHTR2A | |
| Hydrochloric Acid SCHEMBL4437585 | 0.73 | PLD2 (0.53) | OPRM1DRD2HTR1AADRA2AHTR2A | |
| SCHEMBL5000791 | 0.73 | OPRM1 (0.52) | OPRM1DRD2HTR1AADRA2AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121656-A1 | INHIBITORS OF SERINE PALMITOYLTRANSFERASE | Pfizer Products Inc. (US) | 2009-11-25 | — | — | EP | claimed |
| WO-2008084300-A1 | INHIBITORS OF SERINE PALMITOYLTRANSFERASE | PFIZER PRODUCTS INC. (US) | 2008-07-17 | — | — | WO | claimed |