Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LGMN | Q99538 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL904453 | 0.83 | LGMN (0.51) | LGMNALDH1A1MAPTGAAMEN1 | |
| SCHEMBL31248708 | 0.83 | LGMN (0.51) | LGMNALDH1A1MAPTGAAMEN1 | |
| SCHEMBL30443433 | 0.82 | KEAP1 (0.64) | LGMNALDH1A1MAPTGAAMEN1 | |
| SCHEMBL127620 | 0.82 | KEAP1 (0.64) | LGMNALDH1A1MAPTGAAMEN1 | |
| Hydrochloric Acid SCHEMBL23536416 | 0.81 | KEAP1 (0.62) | LGMNALDH1A1MAPTGAAMEN1 | |
| Hydrochloric Acid SCHEMBL9424019 | 0.81 | KEAP1 (0.62) | LGMNALDH1A1MAPTGAAMEN1 | |
| SCHEMBL9059591 | 0.80 | MAPT (0.52) | LGMNALDH1A1MAPTGAAMEN1 | |
| SCHEMBL3727243 | 0.80 | GAA (0.49) | LGMNALDH1A1MAPTGAAKMT2A | |
| SCHEMBL3656962 | 0.80 | MAPT (0.53) | LGMNALDH1A1MAPTGAAMEN1 | |
| SCHEMBL16943272 | 0.80 | ALDH1A1 (0.47) | LGMNALDH1A1POLBSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2132184-A1 | NOVEL PYRIMIDINE DERIVATIVES 698 | AstraZeneca AB (SE) | 2009-12-16 | — | — | EP | disclosed |
| WO-2008104754-A1 | NOVEL PYRIMIDINE DERIVATIVES 698 | ASTRAZENECA AB (SE) | 2008-09-04 | — | — | WO | disclosed |