Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.39 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | CRHBP | P24387 | 1/20 | 0.38 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.38 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1758666 | 0.85 | HTT (0.68) | KMT2AMEN1HTTKDM4EALDH1A1 | |
| SCHEMBL3663772 | 0.81 | HTT (0.51) | KMT2AMEN1HTTKDM4EALDH1A1 | |
| SCHEMBL12861207 | 0.80 | LMNA (0.48) | KMT2AMEN1KDM4EALDH1A1HPGD | |
| SCHEMBL6880359 | 0.79 | KDM4E (0.45) | KMT2AMEN1HTTKDM4EALDH1A1 | |
| SCHEMBL12861217 | 0.79 | KMT2A (0.44) | KMT2AMEN1HTTKDM4EALDH1A1 | |
| SCHEMBL1161063 | 0.77 | THRB (0.47) | KMT2AMEN1HTTKDM4EALDH1A1 | |
| SCHEMBL1844594 | 0.76 | HSD11B1 (0.40) | HTTKDM4EALDH1A1HSD11B1HSD11B2 | |
| SCHEMBL974023 | 0.76 | HSD11B1 (0.40) | HTTKDM4EALDH1A1HSD11B1HSD11B2 | |
| SCHEMBL12696579 | 0.76 | HSD11B1 (0.40) | HTTKDM4EALDH1A1HSD11B1HSD11B2 | |
| SCHEMBL12693260 | 0.76 | HSD11B1 (0.40) | HTTKDM4EALDH1A1HSD11B1HSD11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090270376-A1 | HETEROCYCLIC JANUS KINASE 3 INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2009-10-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270376-A1 | HETEROCYCLIC JANUS KINASE 3 INHIBITORS | JAK3, JAK1, IRAK3 | KMT2A 1246/4885MEN1 2276/4885HTT 1576/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.