SCHEMBL4436336

SCHEMBL4436336

CC(C(=O)CCl)c1ccccc1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FAAH O00519 2/20 0.62
ALDH1A1 P00352 6/20 0.49
LMNA P02545 3/20 0.49
PTGS2 P35354 1/20 0.47
SMN1; SMN2 Q16637 3/20 0.46
TP53 P04637 1/20 0.46
TRPA1 O75762 1/20 0.43
MAPK1 P28482 1/20 0.43
GSK3B P49841 1/20 0.43
HIF1A Q16665 1/20 0.43
MTNR1A P48039 1/20 0.43
MTNR1B P49286 1/20 0.43
HTT P42858 2/20 0.42
NCOA1 Q15788 1/20 0.42
NCOA3 Q9Y6Q9 1/20 0.42
APAF1 O14727 1/20 0.42
NPC1 O15118 1/20 0.41
MAPT P10636 1/20 0.41
RAB9A P51151 1/20 0.41
KMT2A Q03164 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL508956 0.83 PTGS2 (0.50) FAAHPTGS2MTNR1AMTNR1BAPAF1
SCHEMBL11850160 0.82 PTGS1 (0.69) ALDH1A1LMNAPTGS2SMN1; SMN2MAPK1
SCHEMBL4444974 0.82 FAAH (0.66) FAAHALDH1A1LMNASMN1; SMN2GSK3B
SCHEMBL13389325 0.81 ALDH1A1 (0.50) FAAHALDH1A1LMNAPTGS2TRPA1
Methylene Chloride SCHEMBL28307597 0.81 PTGS2 (0.64) ALDH1A1LMNAPTGS2SMN1; SMN2MAPK1
SCHEMBL10728103 0.81 PTGS2 (0.48) FAAHPTGS2TRPA1APAF1CYP2D6
SCHEMBL3410010 0.81 ALDH1A1 (0.50) FAAHALDH1A1LMNAPTGS2TRPA1
SCHEMBL4588469 0.79 PTGS2 (0.47) FAAHPTGS2MTNR1AMTNR1BAPAF1
SCHEMBL7114570 0.79 PTGS2 (0.47) FAAHPTGS2MTNR1AMTNR1BAPAF1
SCHEMBL27332943 0.79 PTGS2 (0.47) FAAHLMNAPTGS2APAF1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025231514-A1 ANTIVIRAL FORMULATIONS Vapour Science (AU) 2025-11-13 WO disclosed
CN-107430129-A Kit for measuring virus 休伯特保健公司 2017-12-01 CN disclosed
CN-107407678-A Kit for measuring virus 休伯特保健公司 2017-11-28 CN disclosed
EP-2134692-A2 QUINOLINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM FOR SELECTIN INHIBITION Wyeth a Corporation of the State of Delaware (US) 2009-12-23 EP disclosed
US-20080255192-A1 2-(1-(4-chlorophenyl)cyclopropyl)-3-hydroxy-8-(trifluoromethoxy)quinoline-4-carboxylic acid; antiinflammtory agents; antagonists of the mammalian adhesion proteins WYETH (US) 2008-10-16 US disclosed
WO-2008121817-A2 QUINOLINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM FOR SELECTIN INHIBITION WYETH (US) 2008-10-09 WO disclosed
EP-1573000-B1 CRYSTAL STRUCTURE OF GLUTAMATE RACEMASE (MURI) ASTRAZENECA AB (SE) 2008-05-07 EP disclosed
EP-1573000-A2 CRYSTAL STRUCTURE OF GLUTAMATE RACEMASE (MURI) AstraZeneca AB (SE) 2005-09-14 EP disclosed
US-20050037478-A1 Crystal structure of glutamate racemase (MurI) ASTRAZENECA AB (SE) 2005-02-17 US disclosed
WO-2004061097-A2 CRYSTAL STRUCTURE OF GLUTAMATE RACEMASE (MURI) ASTRAZENECA AB (SE) 2004-07-22 WO disclosed
US-5474700-A Cleaning composition for degrading targeted proteinaceous contaminants THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (US) 1995-12-12 US disclosed
US-5312749-A Industrial alkaline protease from shipworm bacterium THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (US) 1994-05-17 US disclosed
EP-0502892-A4 THE HUMAN C3B/C4B RECEPTOR (CR1) 1992-11-19 EP disclosed
EP-0502892-A1 THE HUMAN C3b/C4b RECEPTOR (CR1) THE JOHNS HOPKINS UNIVERSITY (US) 1992-09-16 EP disclosed
WO-1991005047-A1 THE HUMAN C3b/C4b RECEPTOR (CR1) THE JOHNS HOPKINS UNIVERSITY (US) 1991-04-18 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080255192-A1 2-(1-(4-chlorophenyl)cyclopropyl)-3-hydroxy-8-(trifluoromethoxy)quinoline-4-carboxylic acid; antiinflammtory agents; antagonists of the mammalian adhesion proteins VCAM1, ICAM1, SELE FAAH 1252/4885ALDH1A1 346/4885LMNA 3699/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.