Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | S100B | P04271 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | LGMN | Q99538 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4442551 | 0.87 | MAPT (0.46) | MAPTHTTGAAKDM4EPTK2B | |
| SCHEMBL426323 | 0.81 | MAPT (0.69) | MAPTHTTGAAMAPK1KDM4E | |
| SCHEMBL1339913 | 0.80 | MAPT (0.61) | MAPTHTTGAAMAPK1KDM4E | |
| SCHEMBL20495516 | 0.80 | ALDH1A1 (0.49) | MAPTHTTGAAMAPK1KDM4E | |
| SCHEMBL1339840 | 0.79 | ALDH1A1 (0.65) | MAPTHTTGAAMAPK1KDM4E | |
| SCHEMBL28327047 | 0.77 | ADRA2C (0.65) | MAPTHTTGAAMAPK1KDM4E | |
| SCHEMBL20166340 | 0.76 | LGMN (0.67) | MAPTHTTGAAMAPK1KDM4E | |
| SCHEMBL4566835 | 0.75 | SMARCA2 (0.54) | MAPTGAAMEN1KMT2AALDH1A1 | |
| SCHEMBL11299409 | 0.73 | MAPT (0.65) | MAPTHTTGAAMAPK1KDM4E | |
| SCHEMBL15922883 | 0.72 | MAPT (0.49) | MAPTHTTGAAMAPK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2132177-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | Novartis Ag (CH) | 2009-12-16 | — | — | EP | disclosed |
| WO-2008106692-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2008-09-04 | — | — | WO | disclosed |