Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CASP6 | P55212 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | BLM | P54132 | 2/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4255042 | 0.85 | MPL (0.40) | ALDH1A1CYP2C9CASP6CYP2C19HSD17B10 | |
| SCHEMBL633391 | 0.84 | MPL (0.33) | ALDH1A1CYP2C9CASP6CYP2C19HSD17B10 | |
| SCHEMBL137432 | 0.77 | RXRA (0.30) | RXRARXRBRXRG | |
| SCHEMBL29329231 | 0.76 | ALDH1A1 (0.41) | ALDH1A1CYP2C9CASP6CYP2C19HSD17B10 | |
| SCHEMBL4885961 | 0.76 | TTR (0.43) | ALDH1A1HSD17B10CYP1A2MEN1KMT2A | |
| Potassium SCHEMBL4171863 | 0.75 | TTR (0.42) | ALDH1A1HSD17B10CYP1A2MEN1KMT2A | |
| SCHEMBL29331370 | 0.75 | ALDH1A1 (0.31) | ALDH1A1CYP2C9CASP6CYP2C19HSD17B10 | |
| SCHEMBL29869219 | 0.74 | RXRA (0.37) | ALDH1A1CYP2C9CASP6CYP2C19HSD17B10 | |
| SCHEMBL47326 | 0.74 | RXRA (0.37) | ALDH1A1CYP2C9CASP6CYP2C19HSD17B10 | |
| SCHEMBL23961228 | 0.73 | RXRA (0.33) | ALDH1A1MAPTRXRARXRBRXRG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240393330-A1 | 4,4-DISUBSTITUTED CYCLOHEXYL BRIDGED HEPTAMETHINE CYANINE DYES AND USES THEREOF | VISEN MEDICAL, INC. | 2024-11-28 | — | — | US | disclosed |
| US-20220178921-A1 | 4,4-DISUBSTITUTED CYCLOHEXYL BRIDGED HEPTAMETHINE CYANINE DYES AND USES THEREOF | VISEN MEDICAL, INC. | 2022-06-09 | — | — | US | disclosed |
| US-11193932-B2 | 4,4-disubstituted cyclohexyl bridged heptamethine cyanine dyes and uses thereof | VISEN MEDICAL, INC. (US) | 2021-12-07 | — | — | US | disclosed |
| US-20200049709-A1 | 4,4-DISUBSTITUTED CYCLOHEXYL BRIDGED HEPTAMETHINE CYANINE DYES AND USES THEREOF | VISEN MEDICAL, INC. | 2020-02-13 | — | — | US | disclosed |
| US-10473658-B2 | 4,4-disubstituted cyclohexyl bridged heptamethine cyanine dyes and uses thereof | VISEN MEDICAL, INC. (US) | 2019-11-12 | — | — | US | disclosed |
| EP-3489309-A1 | 4,4-DISUBSTITUTED CYCLOHEXYL BRIDGED HEPTAMETHINE CYANINE DYES AND USES THEREOF | Visen Medical, Inc. (US) | 2019-05-29 | — | — | EP | disclosed |
| EP-2970674-B1 | 4,4-DISUBSTITUTED CYCLOHEXYL BRIDGED HEPTAMETHINE CYANINE DYES AND USES THEREOF | VISEN MEDICAL INC (US) | 2018-12-12 | — | — | EP | disclosed |
| EP-2118206-B9 | POLYCYCLO DYES AND USE THEREOF | VISEN MEDICAL INC (US) | 2018-08-29 | — | — | EP | disclosed |
| US-20180164312-A1 | 4,4-DISUBSTITUTED CYCLOHEXYL BRIDGED HEPTAMETHINE CYANINE DYES AND USES THEREOF | VISEN MEDICAL INC. | 2018-06-14 | — | — | US | disclosed |
| EP-2118206-B1 | POLYCYCLO DYES AND USE THEREOF | VISEN MEDICAL INC (US) | 2018-04-11 | — | — | EP | disclosed |
| US-9897604-B2 | 4,4-disubstituted cyclohexyl bridged heptamethine cyanine dyes and uses thereof | VISEN MEDICAL, INC. (US) | 2018-02-20 | — | — | US | disclosed |
| US-9365721-B2 | Polycyclo dyes and use thereof | VISEN MEDICAL, INC. (US) | 2016-06-14 | — | — | US | disclosed |
| EP-2970674-A2 | 4,4-DISUBSTITUTED CYCLOHEXYL BRIDGED HEPTAMETHINE CYANINE DYES AND USES THEREOF | VisEn Medical, Inc. (US) | 2016-01-20 | — | — | EP | disclosed |
| US-20140348746-A1 | 4,4-DISUBSTITUTED CYCLOHEXYL BRIDGED HEPTAMETHINE CYANINE DYES AND USES THEREOF | VISEN MEDICAL, INC. (US) | 2014-11-27 | — | — | US | disclosed |
| WO-2014144702-A2 | 4,4-DISUBSTITUTED CYCLOHEXYL BRIDGED HEPTAMETHINE CYANINE DYES AND USES THEREOF | VISEN MEDICAL, INC. (US) | 2014-09-18 | — | — | WO | disclosed |
| US-20130137873-A1 | Polycyclo Dyes and Use Thereof | VISEN MEDICAL, INC. | 2013-05-30 | — | — | US | disclosed |
| US-8221721-B2 | Fluorescent compounds that contain a bridged polycyclo moiety; can be chemically linked to biomolecules such as proteins, nucleic acids, and therapeutic small molecules; can be used for imaging in medical, biological and diagnostic applications, and are particularly useful for in vivo imaging | VISEN MEDICAL, INC. (US) | 2012-07-17 | — | — | US | disclosed |
| EP-2118206-A2 | POLYCYCLO DYES AND USE THEREOF | Visen Medical, Inc. (US) | 2009-11-18 | — | — | EP | disclosed |
| US-20080286207-A1 | Polycyclo Dyes and Use Thereof | VISEN MEDICAL, INC. | 2008-11-20 | — | — | US | disclosed |
| WO-2008100817-A2 | POLYCYCLO DYES AND USE THEREOF | VISEN MEDICAL, INC. (US) | 2008-08-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180164312-A1 | 4,4-DISUBSTITUTED CYCLOHEXYL BRIDGED HEPTAMETHINE CYANINE DYES AND USES THEREOF | CPNE4, LIG4, S100A4 | ALDH1A1 3332/4885CYP2C9 1272/4885CASP6 3047/4885 |
| US-20240393330-A1 | 4,4-DISUBSTITUTED CYCLOHEXYL BRIDGED HEPTAMETHINE CYANINE DYES AND USES THEREOF | CPNE4, LIG4, S100A4 | ALDH1A1 3332/4885CYP2C9 1272/4885CASP6 3047/4885 |
| US-20140348746-A1 | 4,4-DISUBSTITUTED CYCLOHEXYL BRIDGED HEPTAMETHINE CYANINE DYES AND USES THEREOF | CPNE4, LIG4, S100A4 | ALDH1A1 3332/4885CYP2C9 1272/4885CASP6 3047/4885 |
| US-20200049709-A1 | 4,4-DISUBSTITUTED CYCLOHEXYL BRIDGED HEPTAMETHINE CYANINE DYES AND USES THEREOF | CPNE4, LIG4, S100A4 | ALDH1A1 3332/4885CYP2C9 1272/4885CASP6 3047/4885 |
| US-20220178921-A1 | 4,4-DISUBSTITUTED CYCLOHEXYL BRIDGED HEPTAMETHINE CYANINE DYES AND USES THEREOF | CPNE4, LIG4, S100A4 | ALDH1A1 3332/4885CYP2C9 1272/4885CASP6 3047/4885 |
| US-10473658-B2 | 4,4-disubstituted cyclohexyl bridged heptamethine cyanine dyes and uses thereof | CPNE4, LIG4, S100A4 | ALDH1A1 3332/4885CYP2C9 1272/4885CASP6 3047/4885 |
| US-11193932-B2 | 4,4-disubstituted cyclohexyl bridged heptamethine cyanine dyes and uses thereof | CPNE4, LIG4, S100A4 | ALDH1A1 3332/4885CYP2C9 1272/4885CASP6 3047/4885 |
| US-20080286207-A1 | Polycyclo Dyes and Use Thereof | PBRM1, PKD1, PARG | ALDH1A1 4179/4885CYP2C9 3992/4885CASP6 2473/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.