Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | CA5A | P35218 | 1/20 | 0.36 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.36 |
| ▸ | AHR | P35869 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 3/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.33 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.33 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL476639 | 0.84 | ALDH1A1 (0.43) | ALDH1A1S1PR2KDM4EGAAMAPT | |
| SCHEMBL219689 | 0.82 | KDM4E (0.49) | ALDH1A1S1PR2LMNAKDM4EGAA | |
| SCHEMBL362611 | 0.80 | CA5A (0.48) | ALDH1A1CA5AS1PR2AHRLMNA | |
| SCHEMBL30612226 | 0.78 | STAT3 (0.38) | ALDH1A1KDM4ETAS1R3TAS1R1TAS1R2 | |
| SCHEMBL454489 | 0.78 | STAT3 (0.38) | ALDH1A1KDM4ETAS1R3TAS1R1TAS1R2 | |
| SCHEMBL6251916 | 0.76 | CA5A (0.40) | ALDH1A1CA5AS1PR2AHRLMNA | |
| SCHEMBL19690901 | 0.73 | EGFR (0.46) | ALDH1A1S1PR2LMNAKDM4EGAA | |
| SCHEMBL29561847 | 0.73 | SMN1; SMN2 (0.46) | ALDH1A1CA5AS1PR2LMNAKMT2A | |
| SCHEMBL4928556 | 0.73 | SMN1; SMN2 (0.46) | ALDH1A1CA5AS1PR2LMNAKMT2A | |
| SCHEMBL5761347 | 0.73 | ALDH1A1 (0.52) | ALDH1A1CA5ALMNAKDM4ETAS1R3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9238647-B2 | P2X3 receptor antagonists for treatment of pain | MERCK SHARP & DOHME CORP. (US) | 2016-01-19 | — | — | US | disclosed |
| US-20120064181-A1 | P2X3 Receptor Antagonists for Treatment of Pain | MERCK SHARP & DOHME LLC | 2012-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120064181-A1 | P2X3 Receptor Antagonists for Treatment of Pain | P2RX3, P2RX1, P2RX2 | ALDH1A1 2538/4885CA5A 3490/4885S1PR2 328/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.