Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | GSTP1 | P09211 | 9/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | GSTM2 | P28161 | 8/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | NSD2 | O96028 | 1/20 | 0.43 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.43 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.42 |
| ▸ | G6PD | P11413 | 1/20 | 0.41 |
| ▸ | CASP6 | P55212 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3505281 | 0.89 | MEN1 (0.59) | MEN1KMT2AGSTP1KCNH2GSTM2 | |
| SCHEMBL1076589 | 0.85 | MEN1 (0.60) | MEN1KMT2AGSTP1KCNH2GSTM2 | |
| SCHEMBL7463890 | 0.81 | NSD2 (0.62) | MEN1KMT2AGSTP1KCNH2GSTM2 | |
| SCHEMBL7467184 | 0.81 | MEN1 (0.56) | MEN1KMT2AGSTP1KCNH2GSTM2 | |
| SCHEMBL17914175 | 0.78 | MEN1 (0.63) | MEN1KMT2AGSTP1GSTM2NPC1 | |
| SCHEMBL6834711 | 0.77 | MEN1 (0.69) | MEN1KMT2AGSTP1GSTM2NPC1 | |
| SCHEMBL17571858 | 0.77 | MEN1 (0.52) | MEN1KMT2AGSTP1KCNH2GSTM2 | |
| SCHEMBL6259333 | 0.76 | MEN1 (0.54) | MEN1KMT2AGSTP1GSTM2 | |
| SCHEMBL4666212 | 0.75 | GSTM2 (0.77) | MEN1KMT2AGSTM2NPC1RAB9A | |
| SCHEMBL19400408 | 0.75 | GSTM2 (0.77) | MEN1KMT2AGSTM2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090054532-A1 | Modulators of Retinol-Retinol Binding Protein (RBP)-Transthyretin (TTR) Complex Formation | SIRION THERAPEUTICS, INC. (US) | 2009-02-26 | — | — | US | claimed |
| US-20060094063-A1 | Modulators of retinol-retinol binding protein (RBP)-transthyretin (TTR) complex formation | SYTERA, INC. (US) | 2006-05-04 | — | — | US | claimed |
| EP-1660638-B1 | LIPOPARTICLES COMPRISING PROTEINS, METHODS OF MAKING, AND USING THE SAME | INTEGRAL MOLECULAR INC (US) | 2015-12-23 | — | — | EP | disclosed |
| US-9213027-B2 | Lipoparticles comprising proteins, methods of making, and using the same | INTEGRAL MOLECULAR, INC. (US) | 2015-12-15 | — | — | US | disclosed |
| US-20140135230-A1 | Lipoparticles Comprising Proteins, Methods Of Making, And Using The Same | INTEGRAL MOLECULAR, INC. (US) | 2014-05-15 | — | — | US | disclosed |
| US-8574590-B2 | Lipoparticles comprising proteins, methods of making, and using the same | INTEGRAL MOLECULAR, INC. (US) | 2013-11-05 | — | — | US | disclosed |
| US-20120238632-A1 | MODULATORS OF RETINOL-RETINOL BINDING PROTEIN (RBP)-TRANSTHYRETIN (TTR) COMPLEX FORMATION | REVISION THERAPEUTICS, INC. (US) | 2012-09-20 | — | — | US | disclosed |
| US-20090054532-A1 | Modulators of Retinol-Retinol Binding Protein (RBP)-Transthyretin (TTR) Complex Formation | SIRION THERAPEUTICS, INC. (US) | 2009-02-26 | — | — | US | disclosed |
| US-7432307-B2 | Modulators of retinol-retinol binding protein (RBP)-transthyretin (TTR) complex formation | SIRION THERAPEUTICS, INC. (US) | 2008-10-07 | — | — | US | disclosed |
| US-20060094063-A1 | Modulators of retinol-retinol binding protein (RBP)-transthyretin (TTR) complex formation | SYTERA, INC. (US) | 2006-05-04 | — | — | US | disclosed |
| US-20050123563-A1 | Lipoparticles comprising proteins, methods of making, and using the same | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2005-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054532-A1 | Modulators of Retinol-Retinol Binding Protein (RBP)-Transthyretin (TTR) Complex Formation | RBP1, TTR, RBP4 | MEN1 4500/4885KMT2A 4838/4885GSTP1 3209/4885 |
| US-20120238632-A1 | MODULATORS OF RETINOL-RETINOL BINDING PROTEIN (RBP)-TRANSTHYRETIN (TTR) COMPLEX FORMATION | RBP1, TTR, RBP4 | MEN1 4500/4885KMT2A 4838/4885GSTP1 3209/4885 |
| US-20060094063-A1 | Modulators of retinol-retinol binding protein (RBP)-transthyretin (TTR) complex formation | RBP1, TTR, RBP4 | MEN1 4500/4885KMT2A 4838/4885GSTP1 3209/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.