Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | HSD11B1 | P28845 | 9/20 | 0.49 |
| ▸ | CCR5 | P51681 | 2/20 | 0.49 |
| ▸ | YEATS4 | O95619 | 2/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.47 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.47 |
| ▸ | MLLT3 | P42568 | 1/20 | 0.47 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.47 |
| ▸ | YEATS2 | Q9ULM3 | 1/20 | 0.47 |
| ▸ | PLD2 | O14939 | 5/20 | 0.47 |
| ▸ | PLD1 | Q13393 | 5/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4435736 | 0.90 | YEATS4 (0.62) | USP2ALDH1A1LMNAHSD11B1CCR5 | |
| SCHEMBL4440785 | 0.89 | HSD11B1 (0.51) | USP2ALDH1A1LMNAHSD11B1CCR5 | |
| SCHEMBL29848320 | 0.89 | HSD11B1 (0.51) | USP2ALDH1A1LMNAHSD11B1CCR5 | |
| SCHEMBL4443186 | 0.89 | HSD11B1 (0.52) | USP2ALDH1A1LMNAHSD11B1CCR5 | |
| SCHEMBL4434708 | 0.89 | CCR5 (0.53) | USP2ALDH1A1LMNAHSD11B1CCR5 | |
| SCHEMBL4437610 | 0.88 | YEATS4 (0.51) | USP2ALDH1A1LMNAHSD11B1CCR5 | |
| SCHEMBL4444753 | 0.87 | HSD11B1 (0.48) | USP2ALDH1A1LMNAHSD11B1CCR5 | |
| SCHEMBL29198147 | 0.85 | CHRM1 (0.53) | HSD11B1CCR5CHRM2CHRM4CHRM5 | |
| SCHEMBL4440108 | 0.85 | HSD11B1 (0.48) | USP2ALDH1A1LMNAHSD11B1CCR5 | |
| SCHEMBL4446028 | 0.85 | HSD11B1 (0.48) | USP2ALDH1A1LMNAHSD11B1CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121656-A1 | INHIBITORS OF SERINE PALMITOYLTRANSFERASE | Pfizer Products Inc. (US) | 2009-11-25 | — | — | EP | disclosed |
| US-20080287479-A1 | INHIBITORS OF SERINE PALMITOYLTRANSFERASE | PFIZER INC | 2008-11-20 | — | — | US | disclosed |
| US-20080287479-A1 | INHIBITORS OF SERINE PALMITOYLTRANSFERASE | PFIZER INC | 2008-11-20 | — | — | US | disclosed |
| US-20080287479-A1 | INHIBITORS OF SERINE PALMITOYLTRANSFERASE | PFIZER INC | 2008-11-20 | — | — | US | disclosed |
| WO-2008084300-A1 | INHIBITORS OF SERINE PALMITOYLTRANSFERASE | PFIZER PRODUCTS INC. (US) | 2008-07-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080287479-A1 | INHIBITORS OF SERINE PALMITOYLTRANSFERASE | SPTLC1, SPTLC2, CPT1A | USP2 896/4885ALDH1A1 2622/4885LMNA 2105/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.