Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 4/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | CXCR3 | P49682 | 3/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.36 |
| ▸ | IDO1 | P14902 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.36 |
| ▸ | TSPO | P30536 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30317077 | 1.00 | CYP2A6 (0.49) | CYP2A6HTR2ATP53HTR1AHTR7 | |
| SCHEMBL836823 | 0.86 | CYP2A6 (0.50) | CYP2A6HTR2ASLC6A4KCNH2IDO1 | |
| SCHEMBL2761139 | 0.81 | MAOB (0.44) | CYP2A6ALDH1A1 | |
| SCHEMBL11339655 | 0.81 | CYP2A6 (0.53) | CYP2A6IDO1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL16992744 | 0.81 | FFAR1 (0.42) | CYP2A6HTR2ATP53HTR1AHTR7 | |
| SCHEMBL5546270 | 0.80 | CYP3A4 (0.39) | HTR2ATP53HTR1AHTR7HTR6 | |
| SCHEMBL3075954 | 0.80 | CYP2A6 (0.49) | CYP2A6IDO1SLC6A2CYP1A2CYP3A4 | |
| SCHEMBL548158 | 0.79 | IDO1 (0.48) | HTR2ASLC6A4KCNH2IDO1FFAR1 | |
| SCHEMBL549082 | 0.79 | CYP1A2 (0.57) | CYP2A6TP53IDO1CYP1A2CYP3A4 | |
| SCHEMBL29700948 | 0.79 | IDO1 (0.48) | HTR2ASLC6A4KCNH2IDO1FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 190 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102239158-A | Method for preparing a spiroindoline and a precursor thereof | GLAXO GROUP LTD | 2011-11-09 | — | — | CN | claimed |
| EP-2370423-A1 | METHOD FOR PREPARING A SPIROINDOLINE AND A PRECURSOR THEREOF | Glaxo Group Limited (GB) | 2011-10-05 | — | — | EP | claimed |
| US-20110230660-A1 | METHOD FOR PREPARING A SPIROINDOLINE AND A PRECURSOR THEREOF | Method for Preparing a Spiroindoline | 2011-09-22 | — | — | US | claimed |
| WO-2010065704-A1 | METHOD FOR PREPARING A SPIROINDOLINE AND A PRECURSOR THEREOF | GLAXO GROUP LIMITED (GB) | 2010-06-10 | — | — | WO | claimed |
| US-12552783-B2 | Modulators of proteolysis and associated methods of use | ARVINAS OPERATIONS, INC. (US) | 2026-02-17 | — | — | US | disclosed |
| US-12528785-B2 | MDM2 degraders and uses thereof | KYMERA THERAPEUTICS, INC. (US) | 2026-01-20 | — | — | US | disclosed |
| EP-3860654-B1 | PHOTORESPONSIVE NUTLIN DERIVATIVES AND USES THEREOF | UNIV GRONINGEN (NL) | 2025-06-25 | — | — | EP | disclosed |
| CN-116283701-B | Compounds having the structure 4- (substituted aminomethyl) -5-neopentyl-N-substituted pyrrolidine-2-carboxamide | 中国科学院上海药物研究所 | 2025-04-22 | — | — | CN | disclosed |
| US-20240424110-A1 | MDM2 DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. | 2024-12-26 | — | — | US | disclosed |
| US-12054474-B2 | Sulfonyl piperidine derivatives and their use for treating prokineticin mediated diseases | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2024-08-06 | — | — | US | disclosed |
| CN-118047784-A | Small molecule compound with substituted phenyl spiro [ indoline-3, 3' -pyrrolidine ] structure | 中国科学院上海药物研究所 | 2024-05-17 | — | — | CN | disclosed |
| US-11981664-B2 | Photoresponsive nutlin derivatives and uses thereof | RIJKSUNIVERSITEIT GRONINGEN (NL) | 2024-05-14 | — | — | US | disclosed |
| US-20050234097-A1 | Compounds useful for the treatment of diseases | PFIZER INC | 2005-10-20 | — | — | US | disclosed |
| WO-2005090287-A2 | PHENYLETHANOLAMINE DERIVATIVES AS BETA-2 AGONISTS | PFIZER LIMITED (GB) | 2005-09-29 | — | — | WO | disclosed |
| US-6242634-B1 | OF HERBICIDES, HALOPHENYL COMPOUNDS | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2001-06-05 | — | — | US | disclosed |
| US-6100257-A | 2-HALOALKYL,3-(HALOALKYL, ALKENYL, OR ALKYNYL),5-(SUBSTITUTED PHENYL OR HETEROCYCLE),6-ALKYL-PYRIMIDIN-4-ONE COMPOUNDS OF GIVEN STRUCTURE; USE AS HERBICIDES | SUMITOMO CHEMICAL COMPANY, LTD. (JP) | 2000-08-08 | — | — | US | disclosed |
| CN-1198742-A | Pyrimidin-4-one derivatives, their use as herbicides, intermediates for their production and process for producing these compounds | SUMITOMO CHEMICAL CO (JP) | 1998-11-11 | — | — | CN | disclosed |
| EP-0850229-A1 | PYRIMIDIN-4-ONE DERIVATIVES, THEIR USE AS HERBICIDES, INTERMEDIATES FOR THEIR PRODUCTION AND PROCESSES FOR PRODUCING THESE COMPOUNDS | SUMITOMO CHEMICAL COMPANY LIMITED (JP) | 1998-07-01 | — | — | EP | disclosed |
| WO-1997006150-A1 | PYRIMIDIN-4-ONE DERIVATIVES, THEIR USE AS HERBICIDES, INTERMEDIATES FOR THEIR PRODUCTION AND PROCESSES FOR PRODUCING THESE COMPOUNDS | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1997-02-20 | — | — | WO | disclosed |
| US-4369322-A | WITH CYANOGEN CHLORIDE | DEGUSSA AG (DE) | 1983-01-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050234097-A1 | Compounds useful for the treatment of diseases | LTC4S, CYP11B2, CYP11B1 | CYP2A6 150/4885HTR2A 3843/4885TP53 3987/4885 |
| US-12054474-B2 | Sulfonyl piperidine derivatives and their use for treating prokineticin mediated diseases | PROKR1, GIPR, PROKR2 | CYP2A6 2680/4885HTR2A 218/4885TP53 4388/4885 |
| US-20240424110-A1 | MDM2 DEGRADERS AND USES THEREOF | MDM2, USP2, MYCBP2 | CYP2A6 3122/4885HTR2A 2425/4885TP53 7/4885 |
| US-12528785-B2 | MDM2 degraders and uses thereof | MDM2, ADRM1, RBX1 | CYP2A6 781/4885HTR2A 1975/4885TP53 8/4885 |
| US-11981664-B2 | Photoresponsive nutlin derivatives and uses thereof | NUTF2, DNER, TP53 | CYP2A6 3456/4885HTR2A 3823/4885TP53 3/4885 |
| US-12552783-B2 | Modulators of proteolysis and associated methods of use | CRBN, ADRM1, MDM2 | CYP2A6 4321/4885HTR2A 3158/4885TP53 57/4885 |
| US-20110230660-A1 | METHOD FOR PREPARING A SPIROINDOLINE AND A PRECURSOR THEREOF | CCR2, CXCR4, CXCR2 | CYP2A6 1587/4885HTR2A 616/4885TP53 4148/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.