Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 2/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARD | Q03181 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | IKBKB | O14920 | 1/20 | 0.39 |
| ▸ | CHUK | O15111 | 1/20 | 0.39 |
| ▸ | IKBKG | Q9Y6K9 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4441719 | 0.85 | AKR1C3 (0.46) | MEN1KMT2AACHEPPARGPPARD | |
| SCHEMBL65457 | 0.80 | CACNA2D1 (0.37) | NPSR1 | |
| SCHEMBL7873221 | 0.76 | ACHE (0.50) | MAPTKMT2ANPSR1ACHEPPARG | |
| SCHEMBL22209150 | 0.75 | BCHE (0.55) | MEN1MAPTKMT2ANPSR1ACHE | |
| SCHEMBL8324410 | 0.75 | ACHE (0.49) | KMT2ANPSR1PDE4AACHEPPARG | |
| SCHEMBL8334710 | 0.75 | ACHE (0.49) | KMT2ANPSR1PDE4AACHEPPARG | |
| SCHEMBL4441784 | 0.75 | ACHE (0.51) | MEN1MAPTKMT2ANPSR1PDE4A | |
| SCHEMBL7911236 | 0.74 | PDE4A (0.71) | PDE4A | |
| SCHEMBL15577528 | 0.74 | HTR2A (0.41) | MEN1MAPTKMT2ANPSR1ALDH1A1 | |
| SCHEMBL8323966 | 0.73 | GAA (0.45) | NFE2L2KMT2ANPSR1ACHEPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114867-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. Hoffmann-Roche AG (CH) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008107335-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-09-12 | — | — | WO | disclosed |