Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | KCNQ2 | O43526 | 3/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.30 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.30 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2921885 | 0.81 | MAPT (0.44) | ALDH1A1GAANPSR1MEN1KMT2A | |
| SCHEMBL16038585 | 0.77 | GRM5 (0.43) | ALDH1A1GAAKDM4ELMNAMAPT | |
| SCHEMBL7782039 | 0.72 | ALDH1A1 (0.40) | ALDH1A1GAANPSR1MEN1KMT2A | |
| SCHEMBL3555661 | 0.71 | NOTUM (0.47) | ALDH1A1MEN1KMT2AHDAC6MAPT | |
| SCHEMBL4440822 | 0.70 | PRMT5 (0.38) | ALDH1A1GAANPSR1MEN1KMT2A | |
| SCHEMBL2925102 | 0.70 | MAOA (0.40) | ALDH1A1KDM4EHDAC6MAPTTDP1 | |
| SCHEMBL3441635 | 0.69 | HDAC6 (0.43) | ALDH1A1MEN1KMT2AHDAC6MAPT | |
| SCHEMBL2923721 | 0.68 | ESR2 (0.53) | KDM4ELMNAHDAC6MAPTMAPK1 | |
| SCHEMBL6987113 | 0.67 | PDK1 (0.49) | ALDH1A1GAAMEN1KMT2AKDM4E | |
| SCHEMBL2925057 | 0.66 | DRD2 (0.47) | ALDH1A1KDM4EMAPK1L3MBTL1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2132193-B1 | SUBSTITUTED PYRROLIDINE AMIDES, THE PRODUCTION THEREOF, AND THE USE THEREOF AS MEDICATIONS | BOEHRINGER INGELHEIM INT (DE) | 2012-10-24 | — | — | EP | disclosed |
| EP-2132193-A1 | SUBSTITUTED PYRROLIDINE AMIDES, THE PRODUCTION THEREOF, AND THE USE THEREOF AS MEDICATIONS | Boehringer Ingelheim International GmbH (DE) | 2009-12-16 | — | — | EP | disclosed |
| WO-2008116881-A1 | SUBSTITUTED PYRROLIDINE AMIDES, THE PRODUCTION THEREOF, AND THE USE THEREOF AS MEDICATIONS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-10-02 | — | — | WO | disclosed |