Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 5/20 | 0.46 |
| ▸ | CTSL | P07711 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1713153 | 0.81 | CTSL (0.42) | XDHCTSLKDM4EALDH1A1CYP1A2 | |
| SCHEMBL9669758 | 0.80 | XDH (0.50) | XDHCYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL4442001 | 0.78 | XDH (0.43) | XDHCTSLGPR84 | |
| SCHEMBL8840458 | 0.72 | XDH (0.39) | XDHGPR84MAPT | |
| SCHEMBL9667342 | 0.70 | XDH (0.49) | XDHKDM4EALDH1A1KMT2AGAA | |
| SCHEMBL562980 | 0.69 | XDH (0.67) | XDHKDM4EALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL1083326 | 0.68 | XDH (0.44) | XDHKDM4ECYP1A2CYP3A4CYP2D6 | |
| SCHEMBL3431118 | 0.67 | PLA2G2A (0.43) | CTSLKDM4EALDH1A1HPGDPOLB | |
| SCHEMBL7127071 | 0.66 | PDPK1 (0.37) | KDM4EALDH1A1CYP1A2HPGDPOLB | |
| SCHEMBL24846526 | 0.66 | GPR84 (0.50) | XDHCYP1A2CYP3A4CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090111838-A1 | 6-ARYLAMINO-5-CYANO-4-PYRIMIDINONES AS PDE9A INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-04-30 | — | — | US | disclosed |
| US-20090111838-A1 | 6-ARYLAMINO-5-CYANO-4-PYRIMIDINONES AS PDE9A INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-04-30 | — | — | US | disclosed |
| US-7488733-B2 | 6-arylamino-5-cyano-4-pyrimidinones as pde9a inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-02-10 | — | — | US | disclosed |
| US-7488733-B2 | 6-arylamino-5-cyano-4-pyrimidinones as pde9a inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-02-10 | — | — | US | disclosed |
| US-7488733-B2 | 6-arylamino-5-cyano-4-pyrimidinones as pde9a inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-02-10 | — | — | US | disclosed |
| EP-1905765-A1 | 6-arylamino-5-cyano-4-pyrimidinone as PDE9A-inhibitors | Boehringer Ingelheim International GmbH (DE) | 2008-04-02 | — | — | EP | disclosed |
| EP-1905765-A1 | 6-arylamino-5-cyano-4-pyrimidinone as PDE9A-inhibitors | Boehringer Ingelheim International GmbH (DE) | 2008-04-02 | — | — | EP | disclosed |
| EP-1905765-A1 | 6-arylamino-5-cyano-4-pyrimidinone as PDE9A-inhibitors | Boehringer Ingelheim International GmbH (DE) | 2008-04-02 | — | — | EP | disclosed |
| EP-1644339-B1 | 6-ARYLAMINO-5-CYANO-4-PYRIMIDINONES AS PDE9A INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2008-01-23 | — | — | EP | disclosed |
| EP-1644339-B1 | 6-ARYLAMINO-5-CYANO-4-PYRIMIDINONES AS PDE9A INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2008-01-23 | — | — | EP | disclosed |
| US-20070105881-A1 | 6-Arylamino-5-cyano-4-pyrimidinones as pde9a inhibitors | BAYER HEALTHCARE AG (DE) | 2007-05-10 | — | — | US | disclosed |
| US-20070105881-A1 | 6-Arylamino-5-cyano-4-pyrimidinones as pde9a inhibitors | BAYER HEALTHCARE AG (DE) | 2007-05-10 | — | — | US | disclosed |
| US-20070105881-A1 | 6-Arylamino-5-cyano-4-pyrimidinones as pde9a inhibitors | BAYER HEALTHCARE AG (DE) | 2007-05-10 | — | — | US | disclosed |
| CN-1835929-A | 6-arylamino-5-cyano-4-pyrimidinones as pde9a inhibitors | BAYER HEALTHCARE AG (DE) | 2006-09-20 | — | — | CN | disclosed |
| CN-1835929-A | 6-arylamino-5-cyano-4-pyrimidinones as pde9a inhibitors | BAYER HEALTHCARE AG (DE) | 2006-09-20 | — | — | CN | disclosed |
| EP-1644339-A1 | 6-ARYLAMINO-5-CYANO-4-PYRIMIDINONES AS PDE9A INHIBITORS | Bayer HealthCare AG (DE) | 2006-04-12 | — | — | EP | disclosed |
| EP-1644339-A1 | 6-ARYLAMINO-5-CYANO-4-PYRIMIDINONES AS PDE9A INHIBITORS | Bayer HealthCare AG (DE) | 2006-04-12 | — | — | EP | disclosed |
| WO-2004113306-A1 | 6-ARYLAMINO-5-CYANO-4-PYRIMIDINONES AS PDE9A INHIBITORS | BAYER HEALTHCARE AG (DE) | 2004-12-29 | — | — | WO | disclosed |
| WO-2004113306-A1 | 6-ARYLAMINO-5-CYANO-4-PYRIMIDINONES AS PDE9A INHIBITORS | BAYER HEALTHCARE AG (DE) | 2004-12-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090111838-A1 | 6-ARYLAMINO-5-CYANO-4-PYRIMIDINONES AS PDE9A INHIBITORS | PDE9A, PDE2A, PDE5A | XDH 579/4885CTSL 2314/4885KDM4E 404/4885 |
| US-20070105881-A1 | 6-Arylamino-5-cyano-4-pyrimidinones as pde9a inhibitors | PDE9A, PDE2A, PDE5A | XDH 579/4885CTSL 2314/4885KDM4E 404/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.