SCHEMBL444432

SCHEMBL444432

Cc1ncc(CN2CCN(c3cccc(Cl)c3)C(=O)C2)n1Cc1ccc(C#N)cc1

nearest known ligand 0.69

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
FNTA P49354 20/20 0.69
PGGT1B P53609 16/20 0.69
FNTB P49356 14/20 0.69
NRAS P01111 1/20 0.69
HRAS P01112 1/20 0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
L-778123 Free Base SCHEMBL7194384 0.82 FNTA (1.00) FNTAPGGT1BFNTBNRASHRAS
L-778123 Free Base SCHEMBL31237533 0.82 FNTA (1.00) FNTAPGGT1BFNTBNRASHRAS
L-778123 Free Base SCHEMBL1683541 0.82 FNTA (1.00) FNTAPGGT1BFNTBNRASHRAS
L-778123 Free Base SCHEMBL31146896 0.81 FNTA (0.98) FNTAPGGT1BFNTBNRASHRAS
L-778123 Free Base SCHEMBL7652771 0.81 FNTA (0.98) FNTAPGGT1BFNTBNRASHRAS
L-778123 Free Base SCHEMBL7195543 0.81 FNTA (0.98) FNTAPGGT1BFNTBNRASHRAS
SCHEMBL6211931 0.80 FNTA (0.63) FNTAPGGT1BFNTBNRASHRAS
SCHEMBL28783585 0.79 FNTA (0.53) FNTAPGGT1BFNTBNRASHRAS
Hydrochloric Acid SCHEMBL7679520 0.79 FNTA (0.62) FNTAPGGT1BFNTBNRASHRAS
SCHEMBL7659750 0.78 FNTA (0.69) FNTAPGGT1BFNTBNRASHRAS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 275 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20140301976-A1 NOVEL HYDROXAMATES AS THERAPEUTIC AGENTS PHARMACYCLICS, INC. 2014-10-09 US claimed
US-8779171-B2 Hydroxamates as therapeutic agents PHARMACYCLICS, INC. (US) 2014-07-15 US claimed
US-20130142758-A1 NOVEL HYDROXAMATES AS THERAPEUTIC AGENTS PHARMACYCLICS, INC. (US) 2013-06-06 US claimed
US-20260000691-A1 COMPOUNDS, METHODS, AND TREATMENTS FOR ABNORMAL SIGNALING PATHWAYS FOR PRENATAL AND POSTNATAL DEVELOPMENT JENNINGS BARBARA BROOKE (US) 2026-01-01 US disclosed
US-12329766-B2 Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development JENNINGS BARBARA BROOKE (US) 2025-06-17 US disclosed
EP-4552697-A2 PROTEIN KINASE C INHIBITORS AND METHODS OF THEIR USE Novartis AG (CH) 2025-05-14 EP disclosed
EP-3514151-B1 PROTEIN KINASE C INHIBITORS AND METHODS OF THEIR USE NOVARTIS AG (CH) 2025-04-23 EP disclosed
US-20240308979-A1 PROTEIN KINASE C INHIBITORS AND METHODS OF THEIR USE NOVARTIS AG (CH) 2024-09-19 US disclosed
US-11505541-B2 Protein kinase C inhibitors and methods of their use NOVARTIS AG (CH) 2022-11-22 US disclosed
US-20220110954-A1 COMPOUNDS, METHODS, AND TREATMENTS FOR ABNORMAL SIGNALING PATHWAYS FOR PRENATAL AND POSTNATAL DEVELOPMENT JENNINGS BARBARA BROOKE (US) 2022-04-14 US disclosed
US-20210387962-A1 PROTEIN KINASE C INHIBITORS AND METHODS OF THEIR USE NOVARTIS AG (CH) 2021-12-16 US disclosed
US-20020137755-A1 Tyrosine kinase inhibitors BILODEAU MARK T (US) 2002-09-26 US disclosed
US-6420382-B2 QUINOLIN-2-ONE DERIVATIVES TO TREAT ANGIOGENESIS, CANCER, TUMOR GROWTH, ATHEROSCLEROSIS, AGE RELATED MACULAR DEGENERATION, DIABETIC RETINOPATHY AND INFLAMMATORY DISEASES MERCK & CO., INC. 2002-07-16 US disclosed
US-20020072526-A1 Orally active salts with tyrosine kinase activity MERCK & CO., INC. 2002-06-13 US disclosed
US-20010047007-A1 Tyrosine kinase inhibitors MERCK & CO., INC. 2001-11-29 US disclosed
US-20010044451-A1 Tyrosine kinase inhibitors MERCK SHARP & DOHME CORP. 2001-11-22 US disclosed
US-6313138-B1 FOR THERAPY OF ANGIOGENESIS, CANCER, TUMOR GROWTH, ATHEROSCLEROSIS, AGE RELATED MACULAR DEGENERATION, DIABETIC RETINOPATHY, INFLAMMATORY DISEASES IN MAMMALS MERCK & CO., INC. 2001-11-06 US disclosed
US-6306874-B1 ENZYME INHIBITORS SUCH AS ANGIOGENESIS, CANCER, TUMOR GROWTH, ATHEROSCLEROSIS, AGE RELATED MACULAR DEGENERATION, DIABETIC RETINOPATHY, INFLAMMATORY DISEASES, AND THE LIKE IN MAMMALS. MERCK & CO., INC. 2001-10-23 US disclosed
WO-2001062252-A1 TYROSINE KINASE INHIBITORS MERCK & CO., INC. (US) 2001-08-30 WO disclosed
US-6245759-B1 PYRAZOLO(1,5-A)PYRIMIDINE DERIVATIVES; ANTICARCINOGENIC AND ANTITUMOR AGENTS; ATHEROSCLEROSIS, ANGIOGENESIS INHIBITORS MERCK & CO., INC. 2001-06-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240308979-A1 PROTEIN KINASE C INHIBITORS AND METHODS OF THEIR USE PRKCA, PRKCB, PRKCH FNTA 1583/4885PGGT1B 2063/4885FNTB 1494/4885
US-20210387962-A1 PROTEIN KINASE C INHIBITORS AND METHODS OF THEIR USE PRKCA, PRKCB, PRKCH FNTA 1583/4885PGGT1B 2063/4885FNTB 1494/4885
US-20130142758-A1 NOVEL HYDROXAMATES AS THERAPEUTIC AGENTS HDAC1, HDAC3, HDAC5 FNTA 3317/4885PGGT1B 715/4885FNTB 1753/4885
US-20220110954-A1 COMPOUNDS, METHODS, AND TREATMENTS FOR ABNORMAL SIGNALING PATHWAYS FOR PRENATAL AND POSTNATAL DEVELOPMENT PDK1, PKM, PDK2 FNTA 3930/4885PGGT1B 4596/4885FNTB 2686/4885
US-20260000691-A1 COMPOUNDS, METHODS, AND TREATMENTS FOR ABNORMAL SIGNALING PATHWAYS FOR PRENATAL AND POSTNATAL DEVELOPMENT PDK1, IP6K1, IP6K3 FNTA 3572/4885PGGT1B 3876/4885FNTB 2992/4885
US-11505541-B2 Protein kinase C inhibitors and methods of their use PRKCA, PRKCB, PRKCH FNTA 1583/4885PGGT1B 2063/4885FNTB 1494/4885
US-20140301976-A1 NOVEL HYDROXAMATES AS THERAPEUTIC AGENTS HDAC1, HDAC3, HDAC5 FNTA 3317/4885PGGT1B 715/4885FNTB 1753/4885
US-20020072526-A1 Orally active salts with tyrosine kinase activity TEK, FLT1, TIE1 FNTA 3580/4885PGGT1B 3570/4885FNTB 4277/4885
US-20010044451-A1 Tyrosine kinase inhibitors ERBB2, TYRO3, TIE1 FNTA 2966/4885PGGT1B 4287/4885FNTB 3554/4885
US-20010047007-A1 Tyrosine kinase inhibitors ERBB2, TYRO3, TIE1 FNTA 2966/4885PGGT1B 4287/4885FNTB 3554/4885
US-12329766-B2 Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development PDK1, PKM, PDK2 FNTA 3930/4885PGGT1B 4596/4885FNTB 2686/4885
US-20020137755-A1 Tyrosine kinase inhibitors ERBB2, TYRO3, TIE1 FNTA 2966/4885PGGT1B 4287/4885FNTB 3554/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.