Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 2/20 | 0.48 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.48 |
| ▸ | CASP3 | P42574 | 1/20 | 0.48 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.48 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.48 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 9/20 | 0.47 |
| ▸ | GFER | P55789 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | MIF | P14174 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 6/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | POLB | P06746 | 4/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24983896 | 0.85 | HDAC6 (0.47) | HDAC4HDAC7HDAC9HDAC5HDAC6 | |
| SCHEMBL44717 | 0.83 | RAB9A (0.58) | BACE1BACE2CASP3SENP8SENP7 | |
| SCHEMBL44509 | 0.82 | L3MBTL1 (0.60) | BACE1BACE2CASP3SENP8SENP7 | |
| SCHEMBL44586 | 0.81 | HDAC6 (0.43) | HDAC4HDAC7HDAC9HDAC5HDAC6 | |
| SCHEMBL18824382 | 0.79 | HDAC6 (0.59) | HDAC4HDAC5HDAC6 | |
| SCHEMBL43747 | 0.79 | NOTUM (0.53) | BACE1BACE2CASP3SENP8SENP7 | |
| SCHEMBL6389210 | 0.77 | CASP3 (0.56) | BACE1BACE2CASP3SENP8SENP7 | |
| SCHEMBL25789107 | 0.77 | KDM4E (0.60) | BACE1BACE2CASP3SENP8SENP7 | |
| SCHEMBL44657 | 0.76 | KDM4E (0.52) | BACE1BACE2CASP3SENP8SENP7 | |
| SCHEMBL44745 | 0.76 | HDAC6 (0.41) | HDAC4HDAC7HDAC9HDAC5HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | claimed |
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | disclosed |