Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 15/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 12/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 9/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 9/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL44333 | 0.85 | L3MBTL1 (0.58) | L3MBTL1CYP19A1 | |
| SCHEMBL44571 | 0.80 | NOTUM (0.47) | L3MBTL1CYP19A1 | |
| SCHEMBL44368 | 0.79 | SMN1; SMN2 (0.43) | L3MBTL1 | |
| SCHEMBL18824382 | 0.77 | HDAC6 (0.59) | HDAC6HDAC4HDAC8HDAC5L3MBTL1 | |
| SCHEMBL44466 | 0.76 | BACE1 (0.48) | HDAC6HDAC4HDAC7HDAC9HDAC5 | |
| SCHEMBL44399 | 0.76 | KCNH2 (0.40) | CYP19A1 | |
| SCHEMBL44656 | 0.74 | MAPT (0.41) | — | |
| SCHEMBL12377809 | 0.73 | HDAC6 (0.59) | HDAC6HDAC4HDAC8L3MBTL1HDAC1 | |
| SCHEMBL3667489 | 0.72 | F2RL3 (0.54) | CYP19A1 | |
| SCHEMBL44586 | 0.72 | HDAC6 (0.43) | HDAC6HDAC4HDAC8HDAC7HDAC9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | claimed |
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | disclosed |
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | disclosed |