Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4437285 | 0.83 | KMT2A (0.48) | KMT2AMAPTHIF1ACYP2C19ALDH1A1 | |
| SCHEMBL28602564 | 0.83 | MAPT (0.57) | KMT2AMAPTHIF1ACYP2C19ALDH1A1 | |
| SCHEMBL270134 | 0.83 | MAPT (0.57) | KMT2AMAPTHIF1ACYP2C19ALDH1A1 | |
| SCHEMBL6610803 | 0.81 | MAPT (0.55) | KMT2AMAPTHIF1ACYP2C19ALDH1A1 | |
| SCHEMBL25848127 | 0.81 | MAPT (0.61) | KMT2AMAPTHIF1ACYP2C19MAPK1 | |
| SCHEMBL5331416 | 0.81 | MAPT (0.55) | KMT2AMAPTHIF1ACYP2C19ALDH1A1 | |
| SCHEMBL1195864 | 0.79 | CES1 (0.57) | KMT2AMAPTHIF1ACYP2C19ALDH1A1 | |
| Hydrochloric Acid SCHEMBL29273297 | 0.79 | MAPT (0.59) | KMT2AMAPTHIF1ACYP2C19MAPK1 | |
| SCHEMBL28430563 | 0.79 | MAPT (0.53) | KMT2AMAPTHIF1ACYP2C19ALDH1A1 | |
| SCHEMBL4441293 | 0.79 | MAPT (0.53) | KMT2AMAPTHIF1ACYP2C19ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2059503-A1 | AMINOPYRAZOLE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF, AND COMPOSITION FOR PREVENTING OR TREATING ISCHEMIC DISEASES CONTAINING THE SAME | Korea Research Institute Of Chemical Technology (KR) | 2009-05-20 | — | — | EP | claimed |
| WO-2008051047-A1 | AMINOPYRAZOLE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF, AND COMPOSITION FOR PREVENTING OR TREATING ISCHEMIC DISEASES CONTAINING THE SAME | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2008-05-02 | — | — | WO | claimed |
| US-20240239784-A1 | INDOLE COMPOUNDS AND METHODS OF USE | GENZYME CORPORATION | 2024-07-18 | — | — | US | disclosed |
| US-20240239784-A1 | INDOLE COMPOUNDS AND METHODS OF USE | GENZYME CORPORATION | 2024-07-18 | — | — | US | disclosed |
| US-20240239784-A1 | INDOLE COMPOUNDS AND METHODS OF USE | GENZYME CORPORATION | 2024-07-18 | — | — | US | disclosed |
| EP-4396176-A1 | INDOLE COMPOUNDS AND USES THEREOF IN THE TREATEMENT OF CYSTIC FIBROSIS | GENZYME CORPORATION (US) | 2024-07-10 | — | — | EP | disclosed |
| WO-2023034946-A1 | INDOLE COMPOUNDS AND USES THEREOF IN THE TREATEMENT OF CYSTIC FIBROSIS | GENZYME CORPORATION (US) | 2023-03-09 | — | — | WO | disclosed |
| CN-113387781-A | Preparation method of alpha-halogenated ketone compound | 大连凯飞化学股份有限公司 | 2021-09-14 | — | — | CN | disclosed |
| US-20080255192-A1 | 2-(1-(4-chlorophenyl)cyclopropyl)-3-hydroxy-8-(trifluoromethoxy)quinoline-4-carboxylic acid; antiinflammtory agents; antagonists of the mammalian adhesion proteins | WYETH (US) | 2008-10-16 | — | — | US | disclosed |
| WO-2003064359-A1 | BICYCLIC CB2 CANNABINOID RECEPTOR LIGANDS | PHARMOS CORPORATION (US) | 2003-08-07 | — | — | WO | disclosed |
| EP-0044993-B1 | TRIAZOLYLPROPENOL DERIVATIVES, PROCESS FOR THEIR PREPARATION AS WELL AS THEIR USE AS FUNGICIDES AND PLANT GROWTH REGULATORS | BAYER AG (DE) | 1985-05-29 | — | — | EP | disclosed |
| EP-0044993-A2 | Triazolylpropenol derivatives, process for their preparation as well as their use as fungicides and plant growth regulators | BAYER AG (DE) | 1982-02-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240239784-A1 | INDOLE COMPOUNDS AND METHODS OF USE | CFTR, INMT, IDO1 | KMT2A 3610/4885MAPT 4773/4885HIF1A 3982/4885 |
| US-20080255192-A1 | 2-(1-(4-chlorophenyl)cyclopropyl)-3-hydroxy-8-(trifluoromethoxy)quinoline-4-carboxylic acid; antiinflammtory agents; antagonists of the mammalian adhesion proteins | VCAM1, ICAM1, SELE | KMT2A 3971/4885MAPT 3723/4885HIF1A 880/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.