Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 4/20 | 0.65 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.56 |
| ▸ | TACR3 | P29371 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | S1PR3 | Q99500 | 6/20 | 0.46 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.46 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.44 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.44 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.44 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.44 |
| ▸ | ITGAL | P20701 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4443073 | 0.85 | ALDH1A1 (0.56) | PSMB5TACR3ALDH1A1S1PR3S1PR4 | |
| SCHEMBL4452983 | 0.84 | LMNA (0.52) | PSMB5TACR3SMN1; SMN2ALDH1A1S1PR3 | |
| SCHEMBL14024226 | 0.81 | MEN1 (0.54) | PSMB5TACR3SMN1; SMN2ALDH1A1S1PR3 | |
| SCHEMBL4447359 | 0.77 | ITGB1 (0.50) | TACR3ALDH1A1MEN1KMT2A | |
| SCHEMBL4444765 | 0.75 | S1PR3 (0.56) | TACR3SMN1; SMN2ALDH1A1S1PR3S1PR4 | |
| SCHEMBL4454245 | 0.75 | TACR3 (0.54) | TACR3SMN1; SMN2S1PR3KMT2ANFE2L2 | |
| SCHEMBL7987535 | 0.75 | ALDH1A1 (0.67) | GPR139SMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL27409724 | 0.74 | ALDH1A1 (0.61) | PSMB5GPR139SMN1; SMN2ALDH1A1TAS1R3 | |
| SCHEMBL20591807 | 0.73 | KDM4C (0.56) | PSMB5GPR139SMN1; SMN2ALDH1A1TP53 | |
| SCHEMBL20591808 | 0.73 | KDM4C (0.56) | PSMB5GPR139SMN1; SMN2ALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090012010-A1 | Amino acid derivatives as calcium channel blockers | NEUROMED PHRAMACEUTICALS LTD. (CA) | 2009-01-08 | — | — | US | disclosed |
| US-20090012010-A1 | Amino acid derivatives as calcium channel blockers | NEUROMED PHRAMACEUTICALS LTD. (CA) | 2009-01-08 | — | — | US | disclosed |
| US-20090012010-A1 | Amino acid derivatives as calcium channel blockers | NEUROMED PHRAMACEUTICALS LTD. (CA) | 2009-01-08 | — | — | US | disclosed |
| WO-2008141446-A1 | AMINO ACID DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | NEUROMED PHARMACEUTICALS LTD. (CA) | 2008-11-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090012010-A1 | Amino acid derivatives as calcium channel blockers | CACNA1G, CACNA1H, CACNA1I | PSMB5 702/4885GPR139 298/4885TACR3 556/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.