Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 18/20 | 0.78 |
| ▸ | RARA | P10276 | 16/20 | 0.78 |
| ▸ | RARG | P13631 | 15/20 | 0.78 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.78 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.78 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.60 |
| ▸ | CRABP2 | P29373 | 1/20 | 0.48 |
| ▸ | RXRA | P19793 | 2/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9007003 | 0.91 | RARB (0.66) | RARBRARARARGCYP3A4KMT2A | |
| SCHEMBL9817871 | 0.90 | RARA (0.71) | RARBRARARARGCYP3A4KMT2A | |
| SCHEMBL7651593 | 0.89 | RARA (0.63) | RARBRARARARGCYP3A4KMT2A | |
| SCHEMBL19342992 | 0.89 | RARA (0.69) | RARBRARARARGCYP3A4KMT2A | |
| Tazarotene SCHEMBL29512592 | 0.88 | RARA (1.00) | RARBRARARARGCYP3A4KMT2A | |
| Tazarotene SCHEMBL5747908 | 0.88 | RARA (1.00) | RARBRARARARGCYP3A4KMT2A | |
| SCHEMBL19342993 | 0.88 | RARA (0.68) | RARBRARARARGCYP3A4KMT2A | |
| Tazarotene SCHEMBL3134 | 0.88 | RARA (1.00) | RARBRARARARGCYP3A4KMT2A | |
| SCHEMBL19342924 | 0.88 | RARB (0.68) | RARBRARARARGCYP3A4KMT2A | |
| Tazarotene SCHEMBL29397163 | 0.88 | RARA (1.00) | RARBRARARARGCYP3A4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0290130-B1 | ACETYLENES DISUBSTITUTED WITH A PHENYL GROUP AND A HETEROBICYCLIC GROUP HAVING RETINOID LIKE ACTIVITY | ALLERGAN, INC (US) | 1991-11-06 | — | — | EP | claimed |
| US-4810804-A | PSORIASIS | ALLERGAN, INC. (US) | 1989-03-07 | — | — | US | claimed |
| EP-0290130-A1 | Acetylenes disubstituted with a phenyl group and a heterobicyclic group having retinoid like activity | ALLERGAN, INC (US) | 1988-11-09 | — | — | EP | claimed |
| US-8278332-B2 | Photostabilization of retinoids with alkoxycrylene compounds | HALLSTAR INNOVATIONS CORP. (US) | 2012-10-02 | — | — | US | disclosed |
| US-8268294-B2 | Photostabilization of retinoids with alkoxycrylene compounds | HALLSTAR INNOVATIONS CORP. (US) | 2012-09-18 | — | — | US | disclosed |
| US-20120065232-A1 | PHOTOSTABILIZATION OF RETINOIDS WITH ALKOXYCRYLENE COMPOUNDS | HALLSTAR INNOVATIONS CORP. (US) | 2012-03-15 | — | — | US | disclosed |
| US-20110142771-A1 | Photostabilization of Retinoids with Alkoxycrylene Compounds | HALLSTAR INNOVATIONS CORP. (US) | 2011-06-16 | — | — | US | disclosed |
| US-20090324570-A1 | Photostabilization of Retinoids with Alkoxycrylene Compounds | HALLSTAR INNOVATIONS CORP. (US) | 2009-12-31 | — | — | US | disclosed |
| US-5717094-A | 6-THIOCHROMANYL-ETHYNE, 6-CHROMANYL ETHYNE AND 6-TETRAHYDROQUINOLINYL ETHYNE OR THEIR METAL SALTS ARE REACTED WITH SUITABLE HALO SUBSTITUTED PHENYL OR HETEROARYL COMPUNDS | ALLERGAN (US) | 1998-02-10 | — | — | US | disclosed |
| EP-0419132-B1 | Process and intermediates for preparing compounds having a disubstituted acetylene moiety and retinoic acid-like biological activity | ALLERGAN INC (US) | 1995-09-06 | — | — | EP | disclosed |
| US-5248777-A | Inhibitors of ornithine decarboxylase | ALLERGAN, INC. (US) | 1993-09-28 | — | — | US | disclosed |
| EP-0290130-B1 | ACETYLENES DISUBSTITUTED WITH A PHENYL GROUP AND A HETEROBICYCLIC GROUP HAVING RETINOID LIKE ACTIVITY | ALLERGAN, INC (US) | 1991-11-06 | — | — | EP | disclosed |
| US-5053523-A | Chemical intermediate for compounds having retinoic acid-like activity | ALLERGAN, INC. (US) | 1991-10-01 | — | — | US | disclosed |
| US-5023341-A | Acetylene thiochroman | ALLERGAN, INC. (US) | 1991-06-11 | — | — | US | disclosed |
| EP-0419132-A2 | Process and intermediates for preparing compounds having a disubstituted acetylene moiety and retinoic acid-like biological activity | ALLERGAN, INC. (US) | 1991-03-27 | — | — | EP | disclosed |
| US-4810804-A | PSORIASIS | ALLERGAN, INC. (US) | 1989-03-07 | — | — | US | disclosed |
| EP-0290130-A1 | Acetylenes disubstituted with a phenyl group and a heterobicyclic group having retinoid like activity | ALLERGAN, INC (US) | 1988-11-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110142771-A1 | Photostabilization of Retinoids with Alkoxycrylene Compounds | RBP4, RARA, RBP1 | RARB 4/4885RARA 2/4885RARG 6/4885 |
| US-20090324570-A1 | Photostabilization of Retinoids with Alkoxycrylene Compounds | RBP4, RARA, RBP1 | RARB 4/4885RARA 2/4885RARG 6/4885 |
| US-20120065232-A1 | PHOTOSTABILIZATION OF RETINOIDS WITH ALKOXYCRYLENE COMPOUNDS | RBP4, RARA, RBP1 | RARB 4/4885RARA 2/4885RARG 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.