SCHEMBL444996

SCHEMBL444996

COc1ccccc1-n1c(-c2ccccc2)c2ccccc2c1-c1ccccc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AVPR2 P30518 1/20 0.53
AVPR1A P37288 1/20 0.53
ALDH1A1 P00352 4/20 0.51
KDM4E B2RXH2 2/20 0.50
APOBEC3G Q9HC16 1/20 0.50
L3MBTL1 Q9Y468 1/20 0.50
MAPK1 P28482 1/20 0.47
TP53 P04637 2/20 0.47
LMNA P02545 2/20 0.47
MEN1 O00255 3/20 0.46
KMT2A Q03164 3/20 0.46
MAPT P10636 2/20 0.45
ATM Q13315 1/20 0.45
HPGD P15428 2/20 0.44
JUN P05412 1/20 0.44
NFKB1 P19838 1/20 0.44
NFKB2 Q00653 1/20 0.44
RELA Q04206 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
MGLL Q99685 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL445013 0.87 AVPR2 (0.51) AVPR2AVPR1AALDH1A1KDM4EAPOBEC3G
SCHEMBL28181208 0.76 MGLL (0.47) AVPR2AVPR1AALDH1A1KDM4EL3MBTL1
SCHEMBL443050 0.73 MGLL (0.43) ALDH1A1KDM4EL3MBTL1LMNAMEN1
SCHEMBL443060 0.71 LMNA (0.57) ALDH1A1KDM4EL3MBTL1LMNAMEN1
SCHEMBL21354434 0.71 ALDH1A1 (0.58) AVPR2AVPR1AALDH1A1KDM4EAPOBEC3G
SCHEMBL5832232 0.69 AVPR1A (1.00) AVPR2AVPR1A
SCHEMBL443120 0.69 SMN1; SMN2 (0.56) ALDH1A1KDM4EMAPK1KMT2AMAPT
SCHEMBL3493407 0.68 MAPK14 (0.58) AVPR2AVPR1AALDH1A1HTT
SCHEMBL443170 0.68 KDM4E (0.52) AVPR1AALDH1A1KDM4EL3MBTL1MAPK1
SCHEMBL31532182 0.67 AVPR2 (0.55) AVPR2AVPR1AALDH1A1KDM4EAPOBEC3G

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8809543-B2 Electrophotographic photoreceptor, electrophotographic image forming method, electrophotographic image forming apparatus, and process cartridge for electrophotographic image forming apparatus RICOH COMPANY, LTD. (JP) 2014-08-19 US disclosed
US-8809543-B2 Electrophotographic photoreceptor, electrophotographic image forming method, electrophotographic image forming apparatus, and process cartridge for electrophotographic image forming apparatus RICOH COMPANY, LTD. (JP) 2014-08-19 US disclosed
US-20120064443-A1 ELECTROPHOTOGRAPHIC PHOTORECEPTOR, ELECTROPHOTOGRAPHIC IMAGE FORMING METHOD, ELECTROPHOTOGRAPHIC IMAGE FORMING APPARATUS, AND PROCESS CARTRIDGE FOR ELECTROPHOTOGRAPHIC IMAGE FORMING APPARATUS RICOH COMPANY, LTD. (JP) 2012-03-15 US disclosed
US-20120064443-A1 ELECTROPHOTOGRAPHIC PHOTORECEPTOR, ELECTROPHOTOGRAPHIC IMAGE FORMING METHOD, ELECTROPHOTOGRAPHIC IMAGE FORMING APPARATUS, AND PROCESS CARTRIDGE FOR ELECTROPHOTOGRAPHIC IMAGE FORMING APPARATUS RICOH COMPANY, LTD. (JP) 2012-03-15 US disclosed