SCHEMBL4451751

SCHEMBL4451751

COc1cccc(C(=O)CCCCCO[Si](C)(C)C(C)(C)C)c1Cc1c(OC(=O)OC(C)(C)C)c(OC)cc2c1C(=O)c1ccccc1C2=O

nearest known ligand 0.32

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
SLC37A4 O43826 2/20 0.32
HDAC8 Q9BY41 1/20 0.32
HDAC1 Q13547 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2959701 0.88 SLC37A4 (0.38) SLC37A4HDAC8HDAC1
SCHEMBL4455603 0.88 SLC37A4 (0.37) SLC37A4HDAC8HDAC1
SCHEMBL4463509 0.77 MTNR1A (0.40) SLC37A4
SCHEMBL4453653 0.76 SLC37A4 (0.40) SLC37A4
SCHEMBL2948794 0.75 SLC37A4 (0.44) SLC37A4HDAC8HDAC1
SCHEMBL2960224 0.75 SLC37A4 (0.38) SLC37A4
SCHEMBL4463498 0.73 RAB9A (0.40) SLC37A4
SCHEMBL2956199 0.70 SLC37A4 (0.36) SLC37A4
SCHEMBL4463478 0.69 SLC37A4 (0.42) SLC37A4
SCHEMBL4453646 0.69 NPC1 (0.43)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2010474-A1 METHOD FOR THE PRODUCTION OF MUMBAISTATIN DERIVATIVES Sanofi-Aventis (FR) 2009-01-07 EP disclosed
WO-2007121822-A1 METHOD FOR THE PRODUCTION OF MUMBAISTATIN DERIVATIVES SANOFI-AVENTIS (DE) 2007-11-01 WO disclosed