Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 4/20 | 0.44 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.44 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.44 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.44 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.43 |
| ▸ | CASP6 | P55212 | 1/20 | 0.42 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.42 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.42 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.42 |
| ▸ | P2RY14 | Q15391 | 8/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13959317 | 0.92 | MEN1 (0.53) | MEN1POLBKMT2AHTR2CMAPK13 | |
| Trifluoroacetic Acid SCHEMBL4467339 | 0.82 | MAPK13 (0.47) | MEN1POLBKMT2AHTR2CMAPK13 | |
| Trifluoroacetic Acid SCHEMBL4454113 | 0.80 | PKM (0.39) | HTR2CMAPK13MAPK9MAPK12MAPK11 | |
| SCHEMBL4457904 | 0.79 | PIM1 (0.44) | MEN1POLBKMT2AHTR2CMAPK13 | |
| Trifluoroacetic Acid SCHEMBL28665355 | 0.78 | CDK4 (0.43) | MEN1POLBKMT2AHTR2CSIGMAR1 | |
| SCHEMBL13490451 | 0.74 | MEN1 (0.55) | MEN1KMT2AHTR2CSIGMAR1SLC6A2 | |
| Trifluoroacetic Acid SCHEMBL2303613 | 0.73 | HTR2C (0.78) | HTR2CP2RY14ADRA2AADRA2BADRA2C | |
| SCHEMBL4451814 | 0.73 | STS (0.50) | POLBP2RY14GPR119 | |
| Trifluoroacetic Acid SCHEMBL9024551 | 0.72 | SLC18A3 (0.41) | HTR2CSIGMAR1HTR1ASLC6A2SLC6A3 | |
| SCHEMBL13959315 | 0.72 | FFAR4 (0.41) | MEN1KMT2AMAPK11MAPK14FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090030012-A1 | Pyridine, Pyrimidine and Pyrazine Derivatives as Cxcr3 Receptor Modulators | MERCK SHARP & DOHME CORP. | 2009-01-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090030012-A1 | Pyridine, Pyrimidine and Pyrazine Derivatives as Cxcr3 Receptor Modulators | CXCR3, CXCR1, CXCR5 | MEN1 4812/4885POLB 4082/4885KMT2A 4686/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.