Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 9/20 | 0.47 |
| ▸ | MAPK12 | P53778 | 9/20 | 0.47 |
| ▸ | MAPK11 | Q15759 | 9/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 9/20 | 0.47 |
| ▸ | MAPK9 | P45984 | 6/20 | 0.47 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.45 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.45 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | RAF1 | P04049 | 2/20 | 0.42 |
| ▸ | KMO | O15229 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | P2RY14 | Q15391 | 6/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13959343 | 0.92 | MAPK13 (0.50) | MAPK13MAPK12MAPK11MAPK14MAPK9 | |
| Trifluoroacetic Acid SCHEMBL4459394 | 0.83 | CSNK1A1 (0.36) | MAPK13MAPK12MAPK11MAPK14MAPK9 | |
| Trifluoroacetic Acid SCHEMBL4451796 | 0.82 | MEN1 (0.46) | MAPK13MAPK12MAPK11MAPK14MAPK9 | |
| SCHEMBL4466569 | 0.74 | GPR119 (0.50) | P2RY14GPR119 | |
| SCHEMBL13295147 | 0.74 | HPGDS (0.48) | MEN1KMT2APIM1SIGMAR1HTR1A | |
| SCHEMBL13959341 | 0.73 | CCR2 (0.38) | MAPK13MAPK12MAPK11MAPK14MAPK9 | |
| SCHEMBL4466566 | 0.72 | KMO (0.38) | KMO | |
| SCHEMBL13959317 | 0.72 | MEN1 (0.53) | MAPK13MAPK12MAPK11MAPK14MAPK9 | |
| SCHEMBL13294782 | 0.72 | MKNK1 (0.56) | MAPK13MAPK12MAPK11MAPK14MAPK9 | |
| Trifluoroacetic Acid SCHEMBL2303613 | 0.71 | HTR2C (0.78) | P2RY14ADRA2AADRA2BADRA2COPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090030012-A1 | Pyridine, Pyrimidine and Pyrazine Derivatives as Cxcr3 Receptor Modulators | MERCK SHARP & DOHME CORP. | 2009-01-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090030012-A1 | Pyridine, Pyrimidine and Pyrazine Derivatives as Cxcr3 Receptor Modulators | CXCR3, CXCR1, CXCR5 | MAPK13 1632/4885MAPK12 879/4885MAPK11 957/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.