Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 5/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propylene Glycol SCHEMBL16933842 | 0.85 | TDP1 (0.46) | TDP1TSHRHSD17B10LMNAALDH1A1 | |
| SCHEMBL13877207 | 0.82 | TSHR (0.38) | TDP1TSHRLMNAALDH1A1 | |
| SCHEMBL8529610 | 0.82 | TSHR (0.38) | TDP1TSHRLMNAALDH1A1 | |
| Propylene Glycol SCHEMBL15049101 | 0.82 | ALDH1A1 (0.45) | TDP1TSHRLMNAALDH1A1 | |
| SCHEMBL20466528 | 0.80 | TSHR (0.39) | TDP1TSHR | |
| Propylene Glycol SCHEMBL18227008 | 0.80 | LMNA (0.43) | TDP1TSHRLMNAALDH1A1 | |
| Ethylene Glycol SCHEMBL11858084 | 0.79 | TSHR (0.40) | TSHRALDH1A1 | |
| SCHEMBL325804 | 0.79 | TSHR (0.40) | TDP1TSHRLMNAALDH1A1 | |
| SCHEMBL246513 | 0.78 | TSHR (0.41) | TSHR | |
| Propylene Glycol SCHEMBL4899757 | 0.78 | TDP1 (0.56) | TDP1TSHRHSD17B10LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3536683-B1 | POLYISOCYANATE COMPOSITION AND ISOCYANATE POLYMER COMPOSITION | ASAHI CHEMICAL IND (JP) | 2021-11-24 | — | — | EP | disclosed |
| EP-3372579-B1 | POLYISOCYANATE COMPOSITION AND ISOCYANATE POLYMER COMPOSITION | ASAHI CHEMICAL IND (JP) | 2020-10-28 | — | — | EP | disclosed |
| CN-107614596-B | Olefin resin composition, film, and medical container | 住友化学株式会社 | 2020-08-28 | — | — | CN | disclosed |
| EP-3536683-A1 | POLYISOCYANATE COMPOSITION AND ISOCYANATE POLYMER COMPOSITION | Asahi Kasei Kabushiki Kaisha (JP) | 2019-09-11 | — | — | EP | disclosed |
| CN-105254843-B | Polyisocyantates composition, blocked polyisocyanates composition and their manufacturing method | 旭化成株式会社 | 2019-08-06 | — | — | CN | disclosed |
| US-10301417-B2 | Polyisocyanate composition and isocyanate polymer composition | ASAHI KASEI KABUSHIKI KAISHA (JP) | 2019-05-28 | — | — | US | disclosed |
| US-10125212-B2 | Polyisocyanate composition and isocyanate polymer composition | ASAHI KASEI KABUSHIKI KAISHA (JP) | 2018-11-13 | — | — | US | disclosed |
| CN-106008269-B | Polyisocyantates composition and isocyanate polymer composition | 旭化成株式会社 | 2018-10-19 | — | — | CN | disclosed |
| EP-3372579-A1 | POLYISOCYANATE COMPOSITION AND ISOCYANATE POLYMER COMPOSITION | Asahi Kasei Kabushiki Kaisha (JP) | 2018-09-12 | — | — | EP | disclosed |
| US-20170298169-A1 | Polyisocyanate Composition and Isocyanate Polymer Composition | ASAHI KASEI KABUSHIKI KAISHA (JP) | 2017-10-19 | — | — | US | disclosed |
| CN-105254843-A | Polyisocyanate composition, blocking polyisocyanate composition and manufacture methods thereof | ASAHI KASEI CHEMICALS CORP | 2016-01-20 | — | — | CN | disclosed |
| EP-2915803-A1 | POLYISOCYANATE COMPOSITION AND ISOCYANATE POLYMER COMPOSITION | Asahi Kasei Chemicals Corporation (JP) | 2015-09-09 | — | — | EP | disclosed |
| US-20150210631-A1 | Polyisocyanate Composition and Isocyanate Polymer Composition | ASAHI KASEI CHEMICALS CORPORATION (JP) | 2015-07-30 | — | — | US | disclosed |
| CN-104619682-A | Polyisocyanate composition and isocyanate polymer composition | ASAHI KASEI CHEMICALS CORP | 2015-05-13 | — | — | CN | disclosed |
| EP-1958980-B1 | THERMOPLASTIC ELASTOMER COMPOSITION, FOAM PRODUCT, AND PROCESS FOR PRODUCTION OF THE COMPOSITION OR FOAM PRODUCT | JSR CORP (JP) | 2012-10-31 | — | — | EP | disclosed |
| US-20090270525-A1 | THERMOPLASTIC ELASTOMER COMPOSITION, FOAM PRODUCT, AND PROCESS FOR PRODUCTION OF THE COMPOSITION OR FOAM PRODUCT | JSR CORPORATION (JP) | 2009-10-29 | — | — | US | disclosed |
| EP-1958980-A1 | THERMOPLASTIC ELASTOMER COMPOSITION, FOAM PRODUCT, AND PROCESS FOR PRODUCTION OF THE COMPOSITION OR FOAM PRODUCT | JSR Corporation (JP) | 2008-08-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10301417-B2 | Polyisocyanate composition and isocyanate polymer composition | PAH, ALKBH1, ALKBH3 | TDP1 621/4885TSHR 4682/4885HSD17B10 474/4885 |
| US-20170298169-A1 | Polyisocyanate Composition and Isocyanate Polymer Composition | TST, SUDS3, SCLY | TDP1 4009/4885TSHR 4448/4885HSD17B10 592/4885 |
| US-10125212-B2 | Polyisocyanate composition and isocyanate polymer composition | TST, SUDS3, SCLY | TDP1 4009/4885TSHR 4448/4885HSD17B10 592/4885 |
| US-20150210631-A1 | Polyisocyanate Composition and Isocyanate Polymer Composition | TST, SUDS3, SCLY | TDP1 4009/4885TSHR 4448/4885HSD17B10 592/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.