Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 7/20 | 0.49 |
| ▸ | PGR | P06401 | 2/20 | 0.49 |
| ▸ | NR3C2 | P08235 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.39 |
| ▸ | KCNN4 | O15554 | 4/20 | 0.39 |
| ▸ | MDM4 | O15151 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3658752 | 0.83 | NR3C1 (0.34) | NR3C1PGRNR3C2CHRM3 | |
| SCHEMBL4430202 | 0.82 | TAAR1 (0.44) | NR3C1PGRNR3C2CYP3A4 | |
| SCHEMBL4430210 | 0.81 | PDK1 (0.43) | NR3C2CYP3A4HDAC6KIF11 | |
| SCHEMBL14158802 | 0.79 | L3MBTL1 (0.45) | CYP3A4TP53 | |
| SCHEMBL3684124 | 0.78 | CYP19A1 (0.36) | NR3C1PGRNR3C2CYP3A4CYP19A1 | |
| SCHEMBL4437949 | 0.77 | PTPN5 (0.41) | CYP3A4 | |
| SCHEMBL3655647 | 0.76 | NPY5R (0.43) | NR3C1PGRNR3C2CYP3A4KIF11 | |
| SCHEMBL4448695 | 0.76 | HTR2A (0.34) | NR3C1PGRNR3C2 | |
| SCHEMBL291662 | 0.74 | NR3C1 (0.57) | NR3C1PGRNR3C2CYP3A4 | |
| SCHEMBL3679775 | 0.74 | NPSR1 (0.37) | NR3C1PGRNR3C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2051736-A2 | COMPOSITIONS COMPRISING A DISSOCIATED GLUCOCORTICOID RECEPTOR AGONIST AND AN IMMUNOSUPPRESSIVE AGENT FOR TREATING DRY EYE | Bausch & Lomb Incorporated (US) | 2009-04-29 | — | — | EP | disclosed |
| WO-2008005686-A2 | COMPOSITIONS COMPRISING A DISSOCIATED GLUCOCORTICOID RECEPTOR AGONIST AND AN IMMUNOSUPPRESSIVE AGENT FOR TREATING DRY EYE | BAUSCH & LOMB INCORPORATED (US) | 2008-01-10 | — | — | WO | disclosed |