Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.42 |
| ▸ | RAB9A | P51151 | 5/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 10/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4215088 | 0.75 | TP53 (0.46) | NPC1RAB9ATP53ELANEF2 | |
| SCHEMBL28337035 | 0.73 | ELANE (0.50) | NPC1RAB9AELANEKDM4EF2 | |
| SCHEMBL5120623 | 0.71 | HSD17B10 (0.56) | NPC1RAB9AELANEKDM4EF2 | |
| SCHEMBL4787612 | 0.71 | NPC1 (0.47) | NPC1RAB9ATP53ELANEF2 | |
| SCHEMBL1981917 | 0.69 | TP53 (0.44) | NPC1RAB9ATP53ELANEKDM4E | |
| SCHEMBL21874382 | 0.68 | HDAC1 (0.41) | NPC1RAB9AKDM4EMAPTKMT2A | |
| SCHEMBL28335619 | 0.67 | NPSR1 (0.50) | NPC1RAB9APAX8KMT2AMEN1 | |
| SCHEMBL6438919 | 0.67 | TRPV1 (0.50) | NPC1RAB9ATP53KDM4EMAPT | |
| SCHEMBL11121496 | 0.67 | HPGD (0.54) | NPC1RAB9AKDM4EMAPTKMT2A | |
| SCHEMBL11041208 | 0.67 | ALDH1A1 (0.52) | NPC1RAB9ATP53KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009090548-A2 | 3-AZABICYCLO [3.1.0] HEXANE DERIVATIVES AS VANILLOID RECEPTOR LIGANDS | GLENMARK PHARMACEUTICALS, S.A. (US) | 2009-07-23 | — | — | WO | disclosed |