SCHEMBL4454237

SCHEMBL4454237

CC(C)(N)c1cccc(CN)c1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KIF11 P52732 2/20 0.49
TAAR1 Q96RJ0 1/20 0.48
PNMT P11086 1/20 0.47
ENPP2 Q13822 1/20 0.47
LOXL2 Q9Y4K0 2/20 0.46
MAOB P27338 1/20 0.46
HTR2A P28223 1/20 0.46
HTR2C P28335 1/20 0.46
HTR2B P41595 1/20 0.46
CYP1A2 P05177 1/20 0.45
CYP2C19 P33261 1/20 0.45
NOS1 P29475 3/20 0.43
NOS2 P35228 3/20 0.43
IDO1 P14902 2/20 0.43
PRMT6 Q96LA8 1/20 0.43
ALDH1A1 P00352 1/20 0.42
CYP3A4 P08684 1/20 0.42
NFKB1 P19838 1/20 0.42
NOS3 P29474 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3177646 0.85 KIF11 (0.50) KIF11TAAR1HTR2AHTR2CHTR2B
SCHEMBL29755008 0.85 KIF11 (0.50) KIF11TAAR1PNMTENPP2LOXL2
SCHEMBL507652 0.85 KIF11 (0.50) KIF11TAAR1PNMTENPP2LOXL2
SCHEMBL4449174 0.84 TAAR1 (0.70) KIF11TAAR1LOXL2MAOBHTR2A
SCHEMBL27317288 0.84 ENPP2 (0.48) KIF11TAAR1PNMTENPP2LOXL2
Hydrochloric Acid SCHEMBL31072779 0.83 KIF11 (0.49) KIF11TAAR1PNMTENPP2LOXL2
Hydrochloric Acid SCHEMBL3174854 0.83 KIF11 (0.49) KIF11TAAR1MAOBHTR2AHTR2C
Benzylamine SCHEMBL28220475 0.83 LOXL2 (0.58) KIF11TAAR1PNMTLOXL2MAOB
SCHEMBL18766215 0.82 CYP1A2 (0.47) TAAR1ENPP2HTR2AHTR2CHTR2B
SCHEMBL1908518 0.82 ENPP2 (0.50) KIF11TAAR1PNMTENPP2LOXL2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0819000-B1 NODULISPORIC ACID DERIVATIVES MERCK & CO INC (US) 2009-07-08 EP disclosed
EP-1435933-A1 5'-CARBAMOYL-2'-METHYL-1,1'-BIPHENYL-4-CARBOXAMIDE DERIVATIVES AND THEIR USE AS P38 KINASE INHIBITORS GLAXO GROUP LIMITED (GB) 2004-07-14 EP disclosed
WO-2003032970-A1 5'-CARBAMOYL-2'-METHYL-1,1'-BIPHENYL-4-CARBOXAMIDE DERIVATIVES AND THEIR USE AS P38 KINASE INHIBITORS GLAXO GROUP LIMITED (GB) 2003-04-24 WO disclosed
EP-0819000-A4 NODULISPORIC ACID DERIVATIVES MERCK & CO INC (US) 2001-04-11 EP disclosed
US-5962499-A ACARICIDAL, ANTIPARASITIC, INSECTICIDAL AND ANTHELMINTIC AGENTS MERCK & CO., INC. (US) 1999-10-05 US disclosed
CN-1184423-A Nodulisporic acid derivatives MERCK & CO INC (US) 1998-06-10 CN disclosed
EP-0819000-A1 NODULISPORIC ACID DERIVATIVES Merck & Co., Inc. (US) 1998-01-21 EP disclosed
WO-1996029073-A1 NODULISPORIC ACID DERIVATIVES MERCK & CO., INC. (US) 1996-09-26 WO disclosed