Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.62 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7317640 | 0.90 | MAPK8 (0.75) | MAPK8PTGER4HPGDLMNASMN1; SMN2 | |
| SCHEMBL4085475 | 0.90 | MAPK8 (0.62) | MAPK8PTGER4HPGDLMNASMN1; SMN2 | |
| SCHEMBL7368859 | 0.89 | MAPK8 (0.60) | MAPK8PTGER4KMT2A | |
| SCHEMBL7168843 | 0.88 | MAPK8 (0.72) | MAPK8PTGER4KMT2A | |
| SCHEMBL7371983 | 0.88 | MAPK8 (0.69) | MAPK8PTGER4HPGDLMNASMN1; SMN2 | |
| SCHEMBL7371446 | 0.87 | LMNA (0.72) | MAPK8HPGDLMNASMN1; SMN2KMT2A | |
| SCHEMBL4087178 | 0.86 | MAPK8 (0.69) | MAPK8PTGER4HPGDLMNASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6904217 | 0.86 | MAPK8 (0.66) | MAPK8PTGER4HPGDLMNASMN1; SMN2 | |
| SCHEMBL4087209 | 0.85 | PTGER4 (0.58) | MAPK8PTGER4HPGDLMNASMN1; SMN2 | |
| SCHEMBL7368852 | 0.85 | MAPK8 (0.65) | MAPK8PTGER4HPGDLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007517820-A | — | — | 2007-07-05 | — | — | JP | claimed |
| EP-1706118-A1 | NEW PHARMACEUTICAL COMPOSITIONS BASED ON A SCOPINEESTER AND NICOTINAMIDE DERIVATIVES | Boehringer Ingelheim International GmbH (DE) | 2006-10-04 | — | — | EP | claimed |
| WO-2005067929-A1 | NEW PHARMACEUTICAL COMPOSITIONS BASED ON A SCOPINEESTER AND NICOTINAMIDE DERIVATIVES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-07-28 | — | — | WO | claimed |
| US-20050154006-A1 | Pharmaceutical compositions based on a scopineester and nicotinamide derivatives | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-07-14 | — | — | US | claimed |
| EP-1476157-A1 | NICOTINAMIDE DERIVATIVES USEFUL AS PDE4 INHIBITORS | Pfizer Limited (GB) | 2004-11-17 | — | — | EP | claimed |
| US-6756392-B2 | CARBOCYCLIC SECONDARY AMIDES SUCH AS 2-(4-FLUORO-PHENOXY) -N-(4-((2-HYDROXY-3-METHYL-BENZOYL AMINO)-METHYL)-BENZYL)-NICOTINAMIDE, ADMINISTERED FOR PROPHYLAXIS OF RESPIRATORY SYSTEM DISORDERS | PFIZER INC | 2004-06-29 | — | — | US | claimed |
| US-20030195233-A1 | Nicotinamide derivatives useful as PDE4 inhibitors | MAGEE THOMAS V (US) | 2003-10-16 | — | — | US | claimed |
| US-20030191158-A1 | Antiinflamamtory agents; antiallergens | PFIZER INC. | 2003-10-09 | — | — | US | claimed |
| WO-2003068234-A1 | NICOTINAMIDE DERIVATIVES AND A TIOTROPIUM SALT IN COMBINATION FOR THE TREATMENT OF E.G. INFLAMMATORY, ALLERGIC AND RESPIRATORY DISEASES | PFIZER LIMITED (GB) | 2003-08-21 | — | — | WO | claimed |
| WO-2003068232-A1 | NICOTINAMIDE DERIVATIVES USEFUL AS PDE4 INHIBITORS | PFIZER LIMITED (GB) | 2003-08-21 | — | — | WO | claimed |
| EP-2116245-A2 | EGFR kinase inhibitor combinations for treating respiratory and gastrointestinal disorders | Boehringer Ingelheim International GmbH (DE) | 2009-11-11 | — | — | EP | disclosed |
| EP-1706118-A1 | NEW PHARMACEUTICAL COMPOSITIONS BASED ON A SCOPINEESTER AND NICOTINAMIDE DERIVATIVES | Boehringer Ingelheim International GmbH (DE) | 2006-10-04 | — | — | EP | disclosed |
| EP-1651222-A1 | MEDICAMENTS COMPRISING PDE IV INHIBITORS AND AN ANTICHOLINERGIC FOR TREATING RESPIRATORY DISORDERS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2006-05-03 | — | — | EP | disclosed |
| EP-1651208-A1 | MEDICAMENTS COMPRISING PDE IV INHIBITORS AND A NOVEL ANTICHOLINERGIC AND THEIR USE FOR TREATING RESPIRATORY DISORDERS | Boehringer Ingelheim International GmbH (DE) | 2006-05-03 | — | — | EP | disclosed |
| WO-2005067929-A1 | NEW PHARMACEUTICAL COMPOSITIONS BASED ON A SCOPINEESTER AND NICOTINAMIDE DERIVATIVES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-07-28 | — | — | WO | disclosed |
| US-20030191158-A1 | Antiinflamamtory agents; antiallergens | PFIZER INC. | 2003-10-09 | — | — | US | disclosed |
| WO-2003068234-A1 | NICOTINAMIDE DERIVATIVES AND A TIOTROPIUM SALT IN COMBINATION FOR THE TREATMENT OF E.G. INFLAMMATORY, ALLERGIC AND RESPIRATORY DISEASES | PFIZER LIMITED (GB) | 2003-08-21 | — | — | WO | disclosed |
| WO-2003068234-A1 | NICOTINAMIDE DERIVATIVES AND A TIOTROPIUM SALT IN COMBINATION FOR THE TREATMENT OF E.G. INFLAMMATORY, ALLERGIC AND RESPIRATORY DISEASES | PFIZER LIMITED (GB) | 2003-08-21 | — | — | WO | disclosed |
| WO-2003068232-A1 | NICOTINAMIDE DERIVATIVES USEFUL AS PDE4 INHIBITORS | PFIZER LIMITED (GB) | 2003-08-21 | — | — | WO | disclosed |
| WO-2003068232-A1 | NICOTINAMIDE DERIVATIVES USEFUL AS PDE4 INHIBITORS | PFIZER LIMITED (GB) | 2003-08-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030195233-A1 | Nicotinamide derivatives useful as PDE4 inhibitors | PDE4A, PDE4B, PDE4C | MAPK8 1524/4885PTGER4 49/4885HPGD 32/4885 |
| US-20030191158-A1 | Antiinflamamtory agents; antiallergens | NNMT, IL5, HNMT | MAPK8 4288/4885PTGER4 290/4885HPGD 64/4885 |
| US-20050154006-A1 | Pharmaceutical compositions based on a scopineester and nicotinamide derivatives | NAMPT, NNT, XDH | MAPK8 2628/4885PTGER4 1543/4885HPGD 98/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.