Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.42 |
| ▸ | DRD4 | P21917 | 5/20 | 0.42 |
| ▸ | DRD3 | P35462 | 5/20 | 0.42 |
| ▸ | IGF1R | P08069 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | NOS1 | P29475 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.38 |
| ▸ | CACNG2 | Q9Y698 | 1/20 | 0.38 |
| ▸ | STK4 | Q13043 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4469769 | 0.78 | NUDT1 (0.46) | IGF1RNUDT1KDM4ENOS1LMNA | |
| SCHEMBL1791040 | 0.78 | IGF1R (0.48) | DRD2DRD4DRD3IGF1RHRH4 | |
| SCHEMBL4469774 | 0.76 | NUDT1 (0.49) | NUDT1KDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL1787674 | 0.72 | NOTUM (0.58) | NPC1RAB9AKMT2ALMNAMAPT | |
| SCHEMBL4114309 | 0.70 | NOS1 (0.52) | NPC1ARRAB9AKDM4ETSHR | |
| SCHEMBL4363831 | 0.69 | PRKDC (0.52) | KDM4ETSHRALDH1A1HPGDGRIA1 | |
| SCHEMBL3983048 | 0.68 | NOTUM (0.57) | DRD2DRD4DRD3NPC1RAB9A | |
| SCHEMBL4457078 | 0.68 | IGF1R (0.41) | IGF1RSTK4STK3HRH4HRH3 | |
| SCHEMBL4466081 | 0.67 | DRD2 (0.41) | DRD2DRD4DRD3IGF1RNPC1 | |
| SCHEMBL656484 | 0.67 | NOS1 (0.44) | NPC1ARRAB9AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | claimed |