Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUDT1 | P36639 | 1/20 | 0.46 |
| ▸ | IGF1R | P08069 | 3/20 | 0.41 |
| ▸ | CRHBP | P24387 | 1/20 | 0.38 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.38 |
| ▸ | PRKDC | P78527 | 1/20 | 0.36 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | IKBKB | O14920 | 1/20 | 0.34 |
| ▸ | DHFR | P00374 | 2/20 | 0.34 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.33 |
| ▸ | MTOR | P42345 | 2/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4457078 | 0.89 | IGF1R (0.41) | IGF1R | |
| SCHEMBL4462891 | 0.84 | IGF1R (0.43) | IGF1RMAPTKDM4ELMNASMN1; SMN2 | |
| SCHEMBL1790427 | 0.83 | ALDH1A1 (0.36) | IGF1RCYP2D6DHFRLMNASMN1; SMN2 | |
| SCHEMBL4469774 | 0.82 | NUDT1 (0.49) | NUDT1CRHBPCRHR2PRKDCMAP2K7 | |
| SCHEMBL4457095 | 0.78 | DRD2 (0.42) | NUDT1IGF1RMAPTKDM4ELMNA | |
| SCHEMBL4457341 | 0.72 | SLC5A7 (0.44) | IGF1RKDM4ESLC5A7HTTSMN1; SMN2 | |
| SCHEMBL4463976 | 0.72 | IGF1R (0.45) | IGF1RSLC5A7NOS1 | |
| SCHEMBL18932177 | 0.69 | LMNA (0.47) | IGF1RMAPTSLC5A7LMNAHTT | |
| SCHEMBL17979717 | 0.68 | NUDT1 (0.58) | NUDT1CRHBPCRHR2PRKDCMAP2K7 | |
| SCHEMBL4458392 | 0.68 | DHFR (0.51) | DHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | claimed |