Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUDT1 | P36639 | 1/20 | 0.49 |
| ▸ | CRHBP | P24387 | 1/20 | 0.38 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.38 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.38 |
| ▸ | MBOAT4 | Q96T53 | 3/20 | 0.36 |
| ▸ | PRKDC | P78527 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | DHFR | P00374 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | IKBKB | O14920 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4462898 | 0.84 | KDM4E (0.39) | NUDT1PIK3CAMAPTDHFRKDM4E | |
| SCHEMBL4469769 | 0.82 | NUDT1 (0.46) | NUDT1CRHBPCRHR2MAP2K7PRKDC | |
| SCHEMBL4457095 | 0.76 | DRD2 (0.42) | NUDT1MAPTKDM4EHPGDALDH1A1 | |
| SCHEMBL4457348 | 0.72 | HRH3 (0.35) | — | |
| SCHEMBL4463994 | 0.72 | IGF1R (0.31) | — | |
| SCHEMBL4457078 | 0.70 | IGF1R (0.41) | — | |
| SCHEMBL17979717 | 0.68 | NUDT1 (0.58) | NUDT1CRHBPCRHR2MAP2K7PRKDC | |
| SCHEMBL13650781 | 0.68 | NUDT1 (0.61) | NUDT1CRHBPCRHR2MAP2K7PRKDC | |
| SCHEMBL4462891 | 0.67 | IGF1R (0.43) | PIK3CAMAPTKDM4EHPGDALDH1A1 | |
| SCHEMBL9643516 | 0.65 | GAA (0.56) | NUDT1CRHBPCRHR2MAP2K7PRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | claimed |