Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS2R14 | Q9NYV8 | 3/20 | 0.51 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.51 |
| ▸ | DAGLA | Q9Y4D2 | 7/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | MEP1B | Q16820 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4459383 | 0.89 | KEAP1 (0.48) | KEAP1DAGLACYP3A4CYP2D6CYP2C9 | |
| SCHEMBL5064407 | 0.77 | KEAP1 (0.40) | KEAP1DAGLACYP3A4CYP2D6CYP2C9 | |
| SCHEMBL4265325 | 0.72 | PTPN1 (0.57) | KEAP1DAGLA | |
| SCHEMBL15705635 | 0.72 | DAGLA (0.71) | TAS2R14KEAP1DAGLAMEP1BALDH1A1 | |
| SCHEMBL5743320 | 0.71 | KEAP1 (0.35) | TAS2R14KEAP1DAGLACYP3A4CYP2D6 | |
| SCHEMBL4460686 | 0.71 | PTPN1 (0.49) | KEAP1 | |
| SCHEMBL4467405 | 0.71 | DAGLA (0.51) | DAGLACYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL1279479 | 0.69 | TAS2R14 (1.00) | TAS2R14CXCR3KMT2A | |
| SCHEMBL4269569 | 0.68 | MMP2 (0.66) | ALDH1A1 | |
| SCHEMBL4465030 | 0.68 | DAGLA (0.58) | DAGLACYP3A4CYP2D6CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050004369-A1 | Phenyl substituted carboxylic acids | INSTITUTES FOR PHARMACEUTICAL DISCOVERY, L.L.C. | 2005-01-06 | — | — | US | claimed |
| US-7524878-B2 | Phenyl substituted carboxylic acids | THE INSTITUTE FOR PHARMACEUTICALS DISCOVERY LLC (US) | 2009-04-28 | — | — | US | disclosed |
| US-7524878-B2 | Phenyl substituted carboxylic acids | THE INSTITUTE FOR PHARMACEUTICALS DISCOVERY LLC (US) | 2009-04-28 | — | — | US | disclosed |
| US-7524878-B2 | Phenyl substituted carboxylic acids | THE INSTITUTE FOR PHARMACEUTICALS DISCOVERY LLC (US) | 2009-04-28 | — | — | US | disclosed |
| US-7465825-B2 | Phenyl substituted carboxylic acids | THE INSTITUTE FOR PHARMACEUTICAL DISCOVERY, LLC (US) | 2008-12-16 | — | — | US | disclosed |
| US-7465825-B2 | Phenyl substituted carboxylic acids | THE INSTITUTE FOR PHARMACEUTICAL DISCOVERY, LLC (US) | 2008-12-16 | — | — | US | disclosed |
| US-7465825-B2 | Phenyl substituted carboxylic acids | THE INSTITUTE FOR PHARMACEUTICAL DISCOVERY, LLC (US) | 2008-12-16 | — | — | US | disclosed |
| US-20060122257-A1 | Phenyl substituted carboxylic acids | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC | 2006-06-08 | — | — | US | disclosed |
| US-20050004369-A1 | Phenyl substituted carboxylic acids | INSTITUTES FOR PHARMACEUTICAL DISCOVERY, L.L.C. | 2005-01-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060122257-A1 | Phenyl substituted carboxylic acids | PTPA, PTPRS, PTPRO | TAS2R14 3500/4885KEAP1 940/4885DAGLA 1744/4885 |
| US-20050004369-A1 | Phenyl substituted carboxylic acids | PTPA, PTPRS, PTPRO | TAS2R14 3500/4885KEAP1 940/4885DAGLA 1744/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.