Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | PLK1 | P53350 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methyl 2,3,4-Trimethoxybenzoate SCHEMBL1434191 | 0.80 | ALDH1A1 (0.57) | KDM4EPOLBMAPTTDP1ALDH1A1 | |
| SCHEMBL6852879 | 0.78 | CA1 (0.52) | KDM4EPOLBMAPTTDP1ALDH1A1 | |
| SCHEMBL16513023 | 0.77 | HTT (0.50) | KDM4EPOLBMAPTTDP1ALDH1A1 | |
| SCHEMBL15713200 | 0.76 | SMN1; SMN2 (0.40) | KDM4EMAPTTDP1ALDH1A1HSD17B10 | |
| SCHEMBL24136599 | 0.74 | LMNA (0.55) | KDM4EPOLBMAPTTDP1ALDH1A1 | |
| SCHEMBL8894564 | 0.74 | CA1 (0.50) | KDM4EMAPTALDH1A1HSD17B10GAA | |
| SCHEMBL1434290 | 0.74 | MAPT (0.71) | KDM4EPOLBMAPTTDP1ALDH1A1 | |
| SCHEMBL30466421 | 0.74 | LMNA (0.55) | KDM4EPOLBMAPTTDP1ALDH1A1 | |
| SCHEMBL23051546 | 0.74 | MAPT (0.51) | KDM4EPOLBMAPTTDP1ALDH1A1 | |
| SCHEMBL10691520 | 0.73 | ALDH1A1 (0.39) | KDM4EPOLBMAPTTDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2073802-A1 | PHARMACEUTICAL COMBINATIONS | Astex Therapeutics Limited (GB) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008044029-A1 | PHARMACEUTICAL COMBINATIONS | ASTEX THERAPEUTICS LIMITED (GB) | 2008-04-17 | — | — | WO | disclosed |