Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Perflubutane. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 9/20 | 0.50 |
| ▸ | CA1 | P00915 | 8/20 | 0.50 |
| ▸ | MMP1 | P03956 | 5/20 | 0.50 |
| ▸ | MMP2 | P08253 | 5/20 | 0.50 |
| ▸ | MMP9 | P14780 | 5/20 | 0.50 |
| ▸ | MMP8 | P22894 | 5/20 | 0.50 |
| ▸ | MMP13 | P45452 | 5/20 | 0.50 |
| ▸ | CA5A | P35218 | 2/20 | 0.46 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.46 |
| ▸ | F2 | P00734 | 4/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.44 |
| ▸ | PRSS2 | P07478 | 4/20 | 0.44 |
| ▸ | PRSS3 | P35030 | 4/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Perflubutane SCHEMBL7865494 | 0.96 | CA2 (0.48) | CA2CA1MMP1MMP2MMP9 | |
| Sulfuric Acid SCHEMBL19348238 | 0.96 | CA2 (0.52) | CA2CA1MMP1MMP2MMP9 | |
| Perflubutane SCHEMBL10729483 | 0.96 | CA2 (0.48) | CA2CA1MMP1MMP2MMP9 | |
| Perflubutane SCHEMBL1302828 | 0.96 | CA2 (0.48) | CA2CA1MMP1MMP2MMP9 | |
| Sulfuric Acid SCHEMBL2819379 | 0.96 | CA2 (0.52) | CA2CA1MMP1MMP2MMP9 | |
| Sulfuric Acid SCHEMBL1303190 | 0.93 | CA2 (0.50) | CA2CA1MMP1MMP2MMP9 | |
| Sulfuric Acid SCHEMBL19690369 | 0.93 | CA2 (0.50) | CA2CA1MMP1MMP2MMP9 | |
| Perflutren SCHEMBL3944011 | 0.92 | CA5A (0.46) | CA2CA1MMP1MMP2MMP9 | |
| Perflubutane SCHEMBL6557063 | 0.89 | TSHR (0.57) | CA2CA1MMP1MMP2MMP9 | |
| Sulfuric Acid SCHEMBL28980726 | 0.87 | CA2 (0.42) | CA2CA1MMP1MMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2525972-B1 | FLAME-PROTECTED ARTICLE HAVING A HIGH LEVEL OF TRANSMISSION | COVESTRO DEUTSCHLAND AG (DE) | 2016-11-02 | — | — | EP | claimed |
| EP-2785782-B1 | UV-STABILIZED, GLASS-FIBER REINFORCED, FLAME-RETARDANT POLYCARBONATES FOR THE EE AND IT SECTOR | COVESTRO DEUTSCHLAND AG (DE) | 2016-11-02 | — | — | EP | claimed |
| EP-2785783-B1 | ETHYLENE-PROPYLENE-MALEIC ACID ANHYDRIDE COPOLYMER AS IMPACT MODIFIER IN GLASS-FIBER REINFORCED, FLAME-RETARDANT POLYCARBONATES FOR THE EE SECTOR | COVESTRO DEUTSCHLAND AG (DE) | 2016-09-28 | — | — | EP | claimed |
| EP-1910386-B1 | DIARYL ALKYLPHOSPHONATES AND METHOD FOR PREPARING SAME | FRX POLYMERS INC (US) | 2015-09-02 | — | — | EP | claimed |
| US-7569717-B2 | Diaryl alkylphosphonates and method for preparing same | FRX POLYMERS, LLC (US) | 2009-08-04 | — | — | US | claimed |
| EP-1910386-A2 | DIARYL ALKYLPHOSPHONATES AND METHOD FOR PREPARING SAME | Triton Systems Inc. (US) | 2008-04-16 | — | — | EP | claimed |
| US-20070021626-A1 | forming methyldiphenyl phosphonate through reaction of phosphorous trichloride and methanol in presence of an alkylation catalyst methyl iodide; high yield; industrial scale, cost efficiency; free of phosphorus contaminants | FRX POLYMERS, INC. | 2007-01-25 | — | — | US | claimed |
| WO-2007011998-A2 | DIARYL ALKYLPHOSPHONATES AND METHOD FOR PREPARING SAME | TRITON SYSTEMS, INC. (US) | 2007-01-25 | — | — | WO | claimed |
| EP-0664570-B1 | Primary or secondary electrochemical generator having an electrode comprising nanometer size particles | RENATA AG (CH) | 1998-04-08 | — | — | EP | claimed |
| US-5569561-A | Primary or secondary electrochemical generator having a nanoparticulate electrode | RENATA A.G. (CH) | 1996-10-29 | — | — | US | claimed |
| EP-0664570-A1 | Primary or secondary electrochemical generator having an electrode comprising nanometer size particles | Renata AG (CH) | 1995-07-26 | — | — | EP | claimed |
| CN-120201999-A | Antimicrobial compositions | AHV国际有限公司 | 2025-06-24 | — | — | CN | disclosed |
| EP-1910386-B1 | DIARYL ALKYLPHOSPHONATES AND METHOD FOR PREPARING SAME | FRX POLYMERS INC (US) | 2015-09-02 | — | — | EP | disclosed |
| CN-101501048-B | Diaryl alkylphosphonates and method for preparing same | FRX POLYMERS LLC | 2012-11-28 | — | — | CN | disclosed |
| CN-101501048-A | Diaryl alkylphosphonates and method for preparing same | FRX POLYMERS LLC (US) | 2009-08-05 | — | — | CN | disclosed |
| EP-1910386-A2 | DIARYL ALKYLPHOSPHONATES AND METHOD FOR PREPARING SAME | Triton Systems Inc. (US) | 2008-04-16 | — | — | EP | disclosed |
| US-20070021626-A1 | forming methyldiphenyl phosphonate through reaction of phosphorous trichloride and methanol in presence of an alkylation catalyst methyl iodide; high yield; industrial scale, cost efficiency; free of phosphorus contaminants | FRX POLYMERS, INC. | 2007-01-25 | — | — | US | disclosed |
| WO-2007011998-A2 | DIARYL ALKYLPHOSPHONATES AND METHOD FOR PREPARING SAME | TRITON SYSTEMS, INC. (US) | 2007-01-25 | — | — | WO | disclosed |
| EP-0664570-B1 | Primary or secondary electrochemical generator having an electrode comprising nanometer size particles | RENATA AG (CH) | 1998-04-08 | — | — | EP | disclosed |
| EP-0664570-A1 | Primary or secondary electrochemical generator having an electrode comprising nanometer size particles | Renata AG (CH) | 1995-07-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070021626-A1 | forming methyldiphenyl phosphonate through reaction of phosphorous trichloride and methanol in presence of an alkylation catalyst methyl iodide; high yield; industrial scale, cost efficiency; free of phosphorus contaminants | PHOSPHO1, PPIP5K2, IPMK | CA2 2048/4885CA1 3005/4885MMP1 3696/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.