SCHEMBL4459183

SCHEMBL4459183

CC(=O)C(=O)c1c(O)[c]ccc1C(F)(F)F

nearest known ligand 0.36

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
CES2 O00748 3/20 0.35
CES1 P23141 1/20 0.32
KIF11 P52732 1/20 0.30
NOTUM Q6P988 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11229191 0.70 KIF11 (0.31) KIF11
SCHEMBL16793404 0.69
SCHEMBL3338590 0.62 CA2 (0.35) KIF11NOTUM
SCHEMBL1995318 0.62 THRB (0.48) KIF11NOTUM
SCHEMBL1435351 0.61 CES2 (0.75) CES2CES1
SCHEMBL13519060 0.61 THRB (0.63) NOTUM
SCHEMBL27855180 0.60 MAOA (0.38) KIF11NOTUM
SCHEMBL1896544 0.60 KIF11 (0.36) CES2KIF11NOTUM
SCHEMBL7586451 0.60 ESR1 (0.35)
Water SCHEMBL17802301 0.60 CES2 (0.72) CES2CES1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009045083-A2 COMBINATION THERAPY FOR NEUROPROTECTION S.H. PHARMA., LTD (KR) 2009-04-09 WO disclosed