Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.44 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.44 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | MMP14 | P50281 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4467320 | 0.96 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2GAACHRNB2CHRNB4 | |
| SCHEMBL28032524 | 0.88 | ALDH1A1 (0.56) | ALDH1A1SMN1; SMN2GAACHRNB2CHRNB4 | |
| SCHEMBL7876880 | 0.86 | ALDH1A1 (0.56) | ALDH1A1SMN1; SMN2GAACHRNB2CHRNB4 | |
| SCHEMBL8751720 | 0.81 | ALDH1A1 (0.57) | ALDH1A1SMN1; SMN2GAAMAPTCRHBP | |
| SCHEMBL7870367 | 0.80 | ALDH1A1 (0.56) | ALDH1A1SMN1; SMN2GAAMAPTCRHBP | |
| SCHEMBL1854417 | 0.76 | ALDH1A1 (0.61) | ALDH1A1SMN1; SMN2GAAMAPTCRHBP | |
| SCHEMBL513490 | 0.75 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2GAAMAPTCRHBP | |
| SCHEMBL1232308 | 0.75 | MAPT (0.49) | ALDH1A1SMN1; SMN2GAAMAPTCRHBP | |
| SCHEMBL10759692 | 0.74 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2GAAMAPTL3MBTL1 | |
| SCHEMBL7878478 | 0.73 | ALDH1A1 (0.55) | ALDH1A1SMN1; SMN2GAACHRNB2CHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7476663-B2 | Substituted thiophene carboxamides | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-01-13 | — | — | US | disclosed |
| US-20050277628-A1 | Substituted thiophene carboxamides | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-12-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050277628-A1 | Substituted thiophene carboxamides | OTC, SLC22A8, DDC | ALDH1A1 910/4885SMN1; SMN2 1529/4885GAA 3096/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.